{"id":631,"date":"2022-09-11T13:25:04","date_gmt":"2022-09-11T05:25:04","guid":{"rendered":"http:\/\/demo3.aiwalls.com\/cn-news\/index.php\/2022\/09\/11\/%e4%b8%93%e5%ae%b6%e8%ae%ba%e5%9d%9b%ef%bd%9c%e5%88%98%e6%85%a7-%e9%b2%81%e5%87%a4%e6%b0%91-%e9%83%ad%e5%b7%a8%e6%b6%9b%ef%bc%9a%e4%b9%99%e5%9e%8b%e8%82%9d%e7%82%8e%e7%97%85%e6%af%92%e6%a0%b8%e5%bf%83\/"},"modified":"2022-09-12T08:39:49","modified_gmt":"2022-09-12T00:39:49","slug":"%e4%b8%93%e5%ae%b6%e8%ae%ba%e5%9d%9b%ef%bd%9c%e5%88%98%e6%85%a7-%e9%b2%81%e5%87%a4%e6%b0%91-%e9%83%ad%e5%b7%a8%e6%b6%9b%ef%bc%9a%e4%b9%99%e5%9e%8b%e8%82%9d%e7%82%8e%e7%97%85%e6%af%92%e6%a0%b8%e5%bf%83","status":"publish","type":"post","link":"https:\/\/demo3.aiwalls.com\/cn-news\/?p=631","title":{"rendered":"\u4e13\u5bb6\u8bba\u575b\uff5c\u5218\u6167\/\u9c81\u51e4\u6c11\/\u90ed\u5de8\u6d9b\uff1a\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u6838\u5fc3\u86cb\u767d\u53d8\u6784\u8c03\u8282\u5242\u7684\u4f5c\u7528\u673a\u7406\u53ca\u4e34\u5e8a\u7814\u53d1\u548c\u5e94\u7528\u524d\u666f"},"content":{"rendered":"<p 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nm\u7684\u6b63\u4e8c\u5341\u9762\u4f53\u6838\u8863\u58f3\u3002\u6838\u8863\u58f3\u5185\u5305\u88c5\u67093.2 kb\u7684\u90e8\u5206\u53cc\u94fe\u677e\u5f1b\u73af\u72b6DNA(rcDNA)<strong>[1]<\/strong>\u3002HBV\u4ec5\u611f\u67d3\u4eba\u809d\u7ec6\u80de\uff0c\u8fd9\u4e3b\u8981\u662f\u56e0\u4e3a\u809d\u7ec6\u80de\u8868\u9762\u5177\u6709HBV\u7684\u7279\u5f02\u6027\u53d7\u4f53Na+-\u725b\u78fa\u80c6\u9178\u5171\u8f6c\u8fd0\u591a\u80bd(NTCP)<strong>[2]<\/strong>\u3002HBV\u75c5\u6bd2\u9897\u7c92\u4e0e\u809d\u7ec6\u80de\u8868\u9762\u7684NTCP\u7ed3\u5408\uff0c\u901a\u8fc7\u5185\u541e\u9014\u5f84\u8fdb\u5165\u7ec6\u80de\u3002\u968f\u540e\u75c5\u6bd2\u56ca\u819c\u4e0e\u5185\u541e\u4f53\u819c\u878d\u5408\u5c06\u6838\u8863\u58f3\u91ca\u653e\u5165\u7ec6\u80de\u8d28\u4e2d\u3002\u6838\u8863\u58f3\u4f9d\u6b21\u88ab\u8f6c\u8fd0\u81f3\u6838\u5b54\u590d\u5408\u4f53\u5e76\u5728\u6b64\u89e3\u805a\uff0c\u5c06rcDNA\u91ca\u653e\u5165\u7ec6\u80de\u6838\uff0c\u5e76\u88ab\u4fee\u590d\u4ea7\u751f\u5171\u4ef7\u95ed\u5408\u73af\u72b6DNA (cccDNA)<strong>[3]<\/strong>\u3002\u8fdb\u5165\u7ec6\u80de\u6838\u5185\u7684cccDNA\u4e0e\u6838\u5c0f\u4f53\u7ed3\u5408\u5e76\u7ecf\u8fdb\u4e00\u6b65\u4fee\u9970\u5f62\u6210\u5fae\u5c0f\u67d3\u8272\u4f53, \u8f6c\u5f55\u4ea7\u751f5\u79cd\u75c5\u6bd2\u4fe1\u4f7fRNA(mRNA)\u5e76\u7ffb\u8bd1\u4ea7\u751f\u4ee5\u4e0b7\u79cd\u75c5\u6bd2\u86cb\u767d\uff1a3.5 kb pre-C RNA\uff0c\u5176\u7ffb\u8bd1\u4ea7\u751fprecore\u86cb\u767d\uff0c\u8be5\u86cb\u767d\u7ecf\u540e\u7eed\u5207\u5272\u52a0\u5de5\u6700\u7ec8\u6210\u719f\u4e3aHBeAg\u800c\u88ab\u5206\u6ccc\u81f3\u7ec6\u80de\u5916\uff1b\u542b\u4e24\u4e2a\u5f00\u653e\u9605\u8bfb\u6846\u67b6\u76843.5 kb pregenomic RNA (pgRNA)\uff0c\u4e3a\u5178\u578b\u7684\u53cc\u987a\u53cd\u5b50\u8f6c\u5f55\u672c\uff0c\u901a\u8fc7\u5176\u5185\u90e8\u8d77\u59cb\u5bc6\u7801\u5b50\u7684\u5dee\u5f02\u4f7f\u7528\u5206\u522b\u7ffb\u8bd1\u4ea7\u751fCp\u6216\u75c5\u6bd2DNA\u805a\u5408\u9176(pol)\uff1b2.4 kb RNA\u53ef\u7ffb\u8bd1\u4ea7\u751f\u5927\u8868\u9762\u6297\u539f\u86cb\u767d(large HBsAg)\uff1b2.1 kb RNA\u6839\u636e\u5185\u90e8\u8d77\u59cb\u5bc6\u7801\u5b50\u7684\u5dee\u5f02\u4f7f\u7528\u7ffb\u8bd1\u4ea7\u751f\u4e2d\u8868\u9762\u6297\u539f\u86cb\u767d(middle HBsAg)\u548c\u5c0f\u8868\u9762\u6297\u539f\u86cb\u767d(small HBsAg)\uff1b0.7 kb RNA\u7ffb\u8bd1\u4ea7\u751f\u75c5\u6bd2X\u86cb\u767d(HBx)<strong>[1]<\/strong>\u3002<\/p>\n<p id=\"15B94HEQ\">Cp\u86cb\u767d\u7531183\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u7ec4\u6210\uff0c\u901a\u5e38\u4ee5\u540c\u6e90\u4e8c\u805a\u4f53\u5f62\u5f0f\u5b58\u5728\u3002120\u4e2aCp\u4e8c\u805a\u4f53\u53ef\u81ea\u53d1\u88c5\u914d\u5f62\u6210\u6b6320\u9762\u4f53\u6838\u8863\u58f3<strong>[4]<\/strong>\u3002\u4f5c\u4e3a\u75c5\u6bd2\u6838\u8863\u58f3\u7684\u7ed3\u6784\u86cb\u767d\uff0cCp\u53c2\u4e0e\u75c5\u6bd2\u590d\u5236\u7684\u591a\u4e2a\u73af\u8282\u3002\u7b2c\u4e00\uff0c\u5728HBV\u521d\u59cb\u611f\u67d3\u809d\u7ec6\u80de\u8fc7\u7a0b\u4e2d\uff0cCp\u4e0e\u5fae\u7ba1\u8f6c\u8fd0\u86cb\u767d\u53caimportin-\u03b1\/\u03b2\u76f8\u4e92\u8bc6\u522b\u4ecb\u5bfc\u6838\u8863\u58f3\u88ab\u8f6c\u8fd0\u81f3\u6838\u5b54\u590d\u5408\u4f53\u3002\u6838\u5b54\u86cb\u767d\u4e0eCp\u76f8\u4e92\u4f5c\u7528\u8bf1\u5bfc\u6838\u8863\u58f3\u89e3\u805a\uff0c\u5e76\u5c06\u75c5\u6bd2\u57fa\u56e0\u7ec4rcDNA\u91ca\u653e\u5165\u6838\u5f62\u6210cccDNA<strong>[5]<\/strong>\uff1b\u7b2c\u4e8c\uff0cpgRNA\u548c\u7531\u5176\u7ffb\u8bd1\u4ea7\u751f\u7684\u75c5\u6bd2DNA\u805a\u5408\u9176\u590d\u5408\u7269\u6838\u8863\u58f3\u5316\uff0c\u4ece\u800c\u4e3a\u75c5\u6bd2DNA\u590d\u5236\u63d0\u4f9b\u4e86\u76f8\u5bf9\u9694\u79bb\u7684\u53cd\u5e94\u573a\u6240\u4ee5\u963b\u6b62\u7ec6\u80de\u56fa\u6709\u514d\u75ab\u5bf9\u65b0\u5408\u6210\u75c5\u6bd2DNA\u7684\u6a21\u5f0f\u8bc6\u522b\uff0cCp\u672c\u8eab\u4e5f\u5728\u75c5\u6bd2DNA\u7684\u9006\u8f6c\u5f55\u590d\u5236\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u7684\u8c03\u63a7\u4f5c\u7528\u3002\u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u5bbf\u4e3b\u86cb\u767d\u78f7\u9178\u9176\u2160\u50ac\u5316Cp\u7fa7\u57fa\u7aef\u7ed3\u6784\u57df\u53bb\u78f7\u9178\u5316\u4ee5\u8c03\u8282Cp\u4e0epgRNA\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4e0epgRNA-pol\u590d\u5408\u7269\u4e00\u8d77\u88ab\u5305\u88c5\u5165\u6838\u8863\u58f3<strong>[6]<\/strong>\u3002\u5728\u6838\u8863\u58f3\u5185\uff0cpgRNA\u9996\u5148\u88ab\u9006\u8f6c\u5f55\u4ea7\u751f\u8d1f\u94feDNA\uff0c\u5e76\u4ee5\u6b64\u4e3a\u6a21\u677f\u8fdb\u4e00\u6b65\u590d\u5236\u5408\u6210rcDNA\uff1b\u7b2c\u4e09\uff0c\u5728HBV\u611f\u67d3\u7684\u809d\u7ec6\u80de\u4e2d\uff0c\u9664\u5305\u88c5\u6709pgRNA\u53ca\u5904\u4e8e\u590d\u5236\u4e0d\u540c\u9636\u6bb5\u75c5\u6bd2DNA\u7684\u6838\u8863\u58f3\u4e4b\u5916\uff0c\u7edd\u5927\u591a\u6570\u8863\u58f3\u4e3a\u4e0d\u542b\u75c5\u6bd2\u6838\u9178\u7684\u7a7a\u8863\u58f3\u3002\u6709\u522b\u4e8e\u6838\u8863\u58f3\u7684\u88c5\u914d\uff0c\u5728\u7a7a\u8863\u58f3\u88c5\u914d\u8fc7\u7a0b\u4e2d\u5e76\u672a\u53d1\u751fCp\u7fa7\u57fa\u7aef\u7ed3\u6784\u57df\u53bb\u78f7\u9178\u5316\u3002\u56e0\u6b64\uff0c\u4e0e\u5305\u88c5\u6709\u75c5\u6bd2RNA\u6216DNA\u7684\u6838\u8863\u58f3\u4e0d\u540c\uff0c\u7a7a\u8863\u58f3\u662f\u7531\u9ad8\u5ea6\u78f7\u9178\u5316\u7684Cp\u7ec4\u6210<strong>[7]<\/strong>\uff1b\u7b2c\u56db\uff0c\u542b\u6709rcDNA\u7684\u6838\u8863\u58f3\u548c\u7a7a\u8863\u58f3\u90fd\u53ef\u4ee5\u901a\u8fc7Cp\u4e0e\u75c5\u6bd2\u56ca\u819c\u86cb\u767d\u76f8\u4e92\u8bc6\u522b\u4ee5\u542f\u52a8\u75c5\u6bd2\u9897\u7c92\u7684\u88c5\u914d\u548c\u5206\u6ccc<strong>[8]<\/strong>\u3002\u6700\u8fd1\u7684\u7814\u7a76<strong>[9]<\/strong>\u53d1\u73b0\uff0c\u5f53\u6210\u719f\u7684rcDNA\u5f62\u6210\u65f6\uff0c\u6b63\u4e8c\u5341\u9762\u4f53\u6838\u8863\u58f3\u901a\u8fc7\u6539\u53d8Cp\u86cb\u767d\u7684\u6784\u8c61\u800c\u4e0e\u9576\u5d4c\u5728\u591a\u56ca\u6ce1\u4f53\u819c\u4e0a\u7684\u75c5\u6bd2\u56ca\u819c\u86cb\u767d(preS)\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u83b7\u5f97\u5305\u819c\u5e76\u88ab\u91ca\u653e\u51fa\u7ec6\u80de\u5916\uff0c\u8be5\u8fc7\u7a0b\u53d7Cp\u7b2cL60\u3001L95\u3001K96\u548cI126\u7b49\u591a\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u8c03\u63a7\u3002\u800c\u4f4d\u4e8eCp\u6c28\u57fa\u7aef\u7684\u88c5\u914d\u7ed3\u6784\u57df\u548c\u5bcc\u542b\u7cbe\u6c28\u9178\u7684\u7fa7\u57fa\u7aef\u7ed3\u6784\u57df\u4e4b\u95f4\u7684\u8fde\u63a5\u533a\u53ef\u8c03\u63a7\u7a7a\u75c5\u6bd2\u9897\u7c92\u7684\u5305\u88c5\u548c\u5206\u6ccc<strong>[10]<\/strong>\uff1b\u7b2c\u4e94\uff0c\u53c2\u4e0ecccDNA\u6c60\u7684\u5185\u8865\u5145\u3002\u4e0e\u611f\u67d3\u8fc7\u7a0b\u4e2d\u8fdb\u5165\u7ec6\u80de\u8d28\u4e2d\u7684\u6838\u8863\u58f3\u7c7b\u4f3c\uff0c\u7ec6\u80de\u8d28\u4e2d\u590d\u5236\u4ea7\u751f\u7684\u542b\u6709rcDNA\u7684\u5b50\u4ee3\u6210\u719f\u6838\u8863\u58f3\u4e5f\u53ef\u4ee5\u8131\u8863\u58f3\uff0c\u5c06rcDNA\u8f6c\u8fd0\u5165\u7ec6\u80de\u6838\u5185\u5f62\u6210cccDNA\uff0c\u6b64\u5373\u4e3acccDNA\u7684\u7ec6\u80de\u5185\u6269\u589e\u9014\u5f84<strong>[11]<\/strong>\u3002\u7531\u4e8e\u611f\u67d3\u6765\u6e90\u7684\u6210\u719f\u75c5\u6bd2\u6838\u8863\u58f3\u548c\u7ec6\u80de\u5185\u5408\u6210\u7684\u5b50\u4ee3\u6210\u719f\u6838\u8863\u58f3\u7684\u8131\u8863\u58f3\u8fc7\u7a0b\u53ca\u4f4d\u7f6e\u6709\u6240\u5dee\u5f02\uff0ccccDNA\u7684\u4ece\u5934\u5408\u6210\u548c\u7ec6\u80de\u5185\u6269\u589e\u9014\u5f84\u53d7\u7ec6\u80de\u8d28\u4e2d\u6838\u9178\u9176\u7684\u5dee\u5f02\u8c03\u63a7<strong>[12]<\/strong>\u3002\u7531\u6b64\u53ef\u89c1\uff0c\u901a\u8fc7\u6838\u8863\u58f3\u7684\u5305\u88c5\uff0c\u8131\u8863\u58f3\u4ee5\u53ca\u4ecb\u5bfc\u6838\u8863\u58f3\u4e0e\u75c5\u6bd2\u548c\u7ec6\u80de\u86cb\u767d\u7684\u76f8\u4e92\u4f5c\u7528\uff0cCp\u53c2\u4e0e\u4e86\u75c5\u6bd2DNA\u590d\u5236\uff0ccccDNA\u5408\u6210\u548c\u75c5\u6bd2\u9897\u7c92\u7684\u88c5\u914d\u7b49\u591a\u4e2a\u73af\u8282\u3002<\/p>\n<p id=\"15B94HER\">\u9664\u6b64\u4e4b\u5916\uff0c\u4e5f\u6709\u7814\u7a76<strong>[13]<\/strong>\u62a5\u9053\u672a\u53c2\u4e0e\u8863\u58f3\u7ec4\u88c5\u7684\u6e38\u79bbCp\u4e8c\u805a\u4f53\u53ef\u4f5c\u4e3acccDNA\u5fae\u5c0f\u67d3\u8272\u4f53\u7684\u6210\u5206\u5e76\u8c03\u8282cccDNA\u7684\u8f6c\u5f55\u6d3b\u6027\u3002Cp\u4ea6\u88ab\u8bc1\u5b9e\u53ef\u62db\u52df\u5e72\u6270\u7d20\u8bf1\u5bfc\u86cb\u767dAPOBEC 3A\/3B\u81f3cccDNA\uff0c\u5f15\u8d77\u80de\u5627\u5576\u8131\u6c28\u5316\uff0c\u5bfc\u81f4cccDNA\u964d\u89e3<strong>[14-15]<\/strong>\u3002Cp\u4e5f\u53ef\u4e0e\u591a\u79cd\u7ec6\u80deRNA\u7ed3\u5408\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u8c03\u8282HBV RNA\u7684\u4ee3\u8c22<strong>[16]<\/strong>\u3002\u7efc\u4e0a\u6240\u8ff0\uff0cCp\u529f\u80fd\u7684\u591a\u6837\u6027\u610f\u5473\u7740\u9776\u5411\u75c5\u6bd2Cp\u7684\u6297\u75c5\u6bd2\u836f\u7269\u5177\u6709\u6291\u5236\u75c5\u6bd2\u590d\u5236\u5468\u671f\u7684\u591a\u4e2a\u73af\u8282\u4ee5\u53ca\u8c03\u63a7\u75c5\u6bd2\u86cb\u767d\u548c\u6838\u9178\u4ee3\u8c22\u7684\u591a\u79cd\u6f5c\u80fd\u3002<\/p>\n<p id=\"15B94HES\"><strong>2<\/strong><strong>HBV Cp\u53d8\u6784\u8c03\u8282\u5242\u7684\u53d1\u73b0\u53ca\u5206\u7c7b<\/strong><\/p>\n<p id=\"15B94HET\">\u9776\u5411\u75c5\u6bd2Cp\u7684\u6297HBV\u5316\u5408\u7269\u662f\u5f53\u524d\u56fd\u5185\u5916\u5904\u4e8e\u7814\u53d1\u9636\u6bb5\u7684\u70ed\u70b9\u65b0\u836f\u3002\u4f46\u6838\u5fc3\u86cb\u767d\u53d8\u6784\u8c03\u8282\u5242(CpAM)\u7684\u53d1\u73b0\u5219\u53ef\u8ffd\u6eaf\u523020\u4e16\u7eaa90\u5e74\u4ee3\u540e\u671f\u3002\u867d\u7136\u7b2c\u4e00\u4e2a\u88ab\u53d1\u73b0\u7684CpAM\u4e3a\u82ef\u4e19\u70ef\u9170\u80fa\u7c7b\u5316\u5408\u7269(PPA)<strong>[17]<\/strong>\uff0c\u4f46\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u53d1\u9636\u6bb5\u7684CpAM\u4e3b\u8981\u4e3a\u6742\u82b3\u57fa\u4e8c\u6c22\u5627\u5576\u7c7b\u5316\u5408\u7269(HAP)\u548c\u6c28\u78fa\u9170\u82ef\u7532\u9170\u80fa\u7c7b\u5316\u5408\u7269(SBA)\u53ca\u5176\u7b2c\u4e8c\u4ee3\u548c\u7b2c\u4e09\u4ee3\u7684\u884d\u751f\u7269<strong>[18-19]<\/strong>\u3002\u6839\u636e\u8bf1\u5bfcCp\u4e8c\u805a\u4f53\u88c5\u914d\u7684\u4ea7\u7269\u7ed3\u6784\u7684\u4e0d\u540c\uff0cCpAM\u53ef\u5206\u4e3a\u4e24\u79cd\u7c7b\u578b\u3002\u2160\u578bCpAM(type\u2160CpAM)\u4e3b\u8981\u662fHAP\u884d\u751f\u7269\uff0c\u4ee5Bay41-4109\u3001GLS4\u7b49\u4e3a\u4ee3\u8868\uff0c\u8bf1\u5bfcCp\u4e8c\u805a\u4f53\u9519\u8bef\u7ec4\u88c5\u5f62\u6210\u591a\u79cd\u5f62\u6001\u7684\u975e\u8863\u58f3\u7ed3\u6784\u805a\u5408\u7269\uff0c\u5e76\u6700\u7ec8\u5728\u7ec6\u80de\u5185\u88ab\u964d\u89e3<strong>[20-21]<\/strong>\u3002\u2161\u578bCpAM (type\u2161 CpAM)\u4e3b\u8981\u5305\u62ecSBA\u53ca\u5176\u884d\u751f\u7269\uff0c\u4ee5DVR23(AB-423)\u3001ABI-H0731\u3001JNJ-56136379\u548cGLP-26\u7b49\u4e3a\u4ee3\u8868<strong>[19, 22]<\/strong>\uff0c\u53ef\u8bf1\u5bfcCp\u4e8c\u805a\u4f53\u88c5\u914d\u4ea7\u751f\u5f62\u6001\u6b63\u5e38\u4f46\u672a\u5305\u88c5pgRNA\u548c\u75c5\u6bd2DNA\u805a\u5408\u9176\u7684\u7a7a\u6838\u8863\u58f3\u3002\u5c3d\u7ba1\u8fd9\u4e24\u79cd\u7c7b\u578b\u7684CpAM\u8bf1\u5bfc\u4ea7\u751f\u7684Cp\u4e8c\u805a\u4f53\u5305\u88c5\u4ea7\u7269\u7ed3\u6784\u5404\u5f02\uff0c\u4f46\u7686\u963b\u65ad\u4e86\u75c5\u6bd2pgRNA\u548cpol\u5305\u88c5\u5165\u6838\u8863\u58f3\u53ca\u968f\u540e\u7684\u75c5\u6bd2DNA\u590d\u5236\u3002<\/p>\n<p id=\"15B94HEU\"><strong>3<\/strong><strong>HBV Cp\u53d8\u6784\u8c03\u8282\u5242\u7684\u4f5c\u7528\u9776\u70b9\u53ca\u6297\u75c5\u6bd2\u673a\u7406<\/strong><\/p>\n<p id=\"15B94HEV\">Cp\u5728\u809d\u7ec6\u80de\u4e2d\u4ee5\u4e8c\u805a\u4f53\u7684\u5f62\u5f0f\u4f5c\u4e3a\u6838\u8863\u58f3\u7684\u57fa\u672c\u7ed3\u6784\u5355\u4f4d\u3002\u7814\u7a76<strong>[23]<\/strong>\u8868\u660e\uff0c\u6838\u8863\u58f3\u7684\u88c5\u914d\u8fc7\u7a0b\u7531\u76f8\u90bbCp\u4e8c\u805a\u4f53\u4e4b\u95f4\u7684\u758f\u6c34\u6027\u76f8\u4e92\u4f5c\u7528\u529b\u9a71\u52a8\uff0c\u9996\u5148\u53d1\u751f\u7f13\u6162\u805a\u5408\u53cd\u5e94\u5f62\u6210\u516d\u805a\u4f53\uff0c\u518d\u4ee5\u6b64\u4e3a\u57fa\u7840\u52a0\u901f\u805a\u5408\u88c5\u914d\u5f62\u6210\u6b6320\u9762\u4f53\u6838\u8863\u58f3\u7ed3\u6784\u3002CpAM\u7ed3\u5408\u4e8e\u76f8\u90bbCp\u4e8c\u805a\u4f53\u76f8\u4e92\u4f5c\u7528\u754c\u9762\u4e0a\u7684\u758f\u6c34\u6027\u53e3\u888b(HAP pocket)\u4ee5\u589e\u5f3aCp\u4e8c\u805a\u4f53\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u52a0\u901fCp\u4e8c\u805a\u4f53\u7684\u88c5\u914d\u8fc7\u7a0b<strong>[24-25]<\/strong>\u3002\u57fa\u4e8e\u6b64\uff0c\u8be5\u7c7b\u5316\u5408\u7269\u88ab\u547d\u540d\u4e3aCpAM\u6216\u6838\u8863\u58f3\u88c5\u914d\u8c03\u8282\u5242\uff0c\u800c\u975e\u6838\u8863\u58f3\u88c5\u914d\u6291\u5236\u5242\u3002HAP pocket\u753125\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u5f62\u6210\u3002\u56e0\u5316\u5b66\u7ed3\u6784\u7684\u5dee\u5f02\uff0c\u4e0d\u540cCpAM\u4e0e\u201cHAP\u201d\u53e3\u888b\u4e2d\u4e0d\u540c\u7684\u6c28\u57fa\u9178\u4fa7\u94fe\u7ed3\u5408\u800c\u5e72\u6270\u6838\u8863\u58f3\u7ec4\u88c5\u7684\u901f\u7387\u548c\u8fc7\u7a0b\uff0c\u4ece\u800c\u5bfc\u81f4\u88c5\u914d\u4ea7\u7269\u7684\u8868\u578b\u5dee\u5f02\u3002\u5229\u7528Y132A\u7a81\u53d8\u7684Cp\u4e0d\u80fd\u88c5\u914d\u5f62\u6210\u6838\u8863\u58f3\uff0c\u4f46\u53ef\u5f62\u6210\u7a33\u5b9a\u516d\u805a\u4f53\u5e76\u4e0eCpAM\u5f62\u6210\u5171\u7ed3\u6676\u7684\u7279\u6027\uff0c\u5bf9\u6bd4\u7814\u7a76HAP_R01\u548cSBA_R01\u4e0eCp\u7684\u7ed3\u5408\u7279\u6027\u53d1\u73b0\u4e24\u8005\u867d\u7686\u7ed3\u5408Cp\u4e8c\u805a\u4f53\u754c\u9762\u95f4\u7684\u201cHAP\u201d\u53e3\u888b\u5e76\u4e0eT33\u7ed3\u5408\uff0c\u4f46HAP_R01\u7684\u567b\u5511\u57fa\u56e2\u53ef\u7ed3\u5408\u4e8e\u5176\u4e2d\u7684\u4e00\u4e2a\u5c0f\u53e3\u888b(sub-pocket)\uff0c\u5e76\u4e0eP25\u7ed3\u5408\u3002\u4e0e\u6b64\u7ed3\u6784\u751f\u7269\u5b66\u53d1\u73b0\u76f8\u5bf9\u5e94\uff0cCp\u6c28\u57fa\u9178\u7a81\u53d8\u5206\u6790<strong>[26]<\/strong>\u8bc1\u660eCp\u7684T33N\u7a81\u53d8\u5bf9HAP_R01\u548cSBA_R01\u5747\u4ea7\u751f\u8010\u836f\uff0c\u800cCp\u7684P25A\u6216P25S\u7a81\u53d8\u53ea\u5bf9HAP_R01\u8010\u836f\u3002\u501f\u52a9\u51b7\u51bb\u7535\u955c\u5206\u6790CpAM\u4e0e\u4f53\u5916\u88c5\u914d\u7684\u7a7a\u8863\u58f3\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0HAP1\u548cAT-130\u5747\u7ed3\u5408\u4e8eHAP\u53e3\u888b\u5e76\u5f15\u8d77\u6838\u8863\u58f3\u56db\u7ea7\u7ed3\u6784\u7684\u53d8\u5316\uff0c\u4f46AT-130\u4e5f\u53ef\u4ee3\u507f\u6027\u5730\u5bfc\u81f4\u6838\u8863\u58f3\u88c5\u914d\u8fc7\u7a0b\u4e2d\u4e09\u7ea7\u7ed3\u6784\u7684\u53d8\u5316<strong>[24, 27]<\/strong>\u3002\u663e\u800c\u6613\u89c1\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u7ed3\u6784\u751f\u7269\u5b66\u548c\u8010\u836f\u7a81\u53d8\u5206\u6790\u7814\u7a76\u7ed3\u679c\u53ef\u4ee5\u8f85\u52a9\u89e3\u91ca\u4e24\u79cd\u7c7b\u578bCpAM\u7684\u8868\u578b\u548c\u4f5c\u7528\u673a\u7406\u7684\u5dee\u5f02\uff0c\u4f46CpAM\u5bf9\u6838\u8863\u58f3\u88c5\u914d\u8fc7\u7a0b\u7684\u8c03\u63a7\u673a\u7406\u6709\u5f85\u4e8e\u8fdb\u4e00\u6b65\u751f\u7269\u7269\u7406\u5b66\u548c\u7ed3\u6784\u751f\u7269\u5b66\u7684\u7814\u7a76\u3002<\/p>\n<p id=\"15B94HF0\">\u9664\u5e72\u6270\u6838\u8863\u58f3\u7684\u88c5\u914d\u4e4b\u5916\uff0cCpAM\u5728\u8f83\u9ad8\u836f\u7269\u6d53\u5ea6\u4e0b\u4e5f\u53ef\u4ee5\u8bf1\u5bfc\u5df2\u88c5\u914d\u7684\u6838\u8863\u58f3\u7ed3\u6784\u6539\u53d8\u751a\u81f3\u89e3\u805a<strong>[28-29]<\/strong>\u3002\u5982\u524d\u6240\u8ff0\uff0c\u501f\u52a9\u51b7\u51bb\u7535\u955c\u7ed3\u6784\u5206\u6790\u8bc1\u5b9eCpAM\u53ef\u7ed3\u5408\u4e8e\u5df2\u88c5\u914d\u7684\u6838\u8863\u58f3\u4e2d\u7684HAP\u53e3\u888b\u4ece\u800c\u6539\u53d8\u8863\u58f3\u7684\u4e09\u7ea7\u548c\u56db\u7ea7\u7ed3\u6784\u3002\u8fd9\u4e9b\u7ed3\u6784\u7684\u6539\u53d8\u5728\u4e00\u5b9a\u60c5\u51b5\u4e0b\u53ef\u4ee5\u5bfc\u81f4\u6838\u8863\u58f3\u5728\u743c\u8102\u7cd6\u51dd\u80f6\u7535\u6cf3\u5b9e\u9a8c\u4e2d\u8fc1\u79fb\u7387\u53d1\u751f\u6539\u53d8<strong>[30]<\/strong>\u3002\u540c\u65f6\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u53cc\u94feDNA\u76f8\u5bf9\u5177\u6709\u521a\u6027\u5e76\u4ece\u6838\u8863\u58f3\u5185\u90e8\u4ea7\u751f\u5f20\u529b\uff0c\u4f7f\u5f97CpAM\u7ed3\u5408HAP\u53e3\u888b\u540e\u66f4\u6613\u8bf1\u5bfc\u6210\u719f\u6838\u8863\u58f3\u89e3\u805a\u7684\u7f18\u6545\uff0c\u6709\u7814\u7a76<strong>[31]<\/strong>\u53d1\u73b0CpAM\u53ef\u9009\u62e9\u6027\u5730\u8bf1\u5bfc\u542b\u6709\u53cc\u94feDNA\u7684\u6210\u719f\u6838\u8863\u58f3\u7684\u89e3\u805a\u3002<\/p>\n<p id=\"15B94HF1\">\u4e0eCpAM\u5bf9\u6838\u8863\u58f3\u88c5\u914d\u548c\u89e3\u805a\u7684\u4f5c\u7528\u76f8\u7b26\uff0c\u5728HBV\u611f\u67d3\u7684\u809d\u7ec6\u80de\u4e2d\uff0cCpAM\u8bf1\u5bfcCp\u88c5\u914d\u4ea7\u751f\u975e\u8863\u58f3\u7ed3\u6784\u805a\u5408\u7269\u6216\u7a7a\u8863\u58f3\u4ece\u800c\u5e72\u6270HBV DNA\u590d\u5236\uff0c\u6700\u7ec8\u6291\u5236\u611f\u67d3\u6027\u75c5\u6bd2\u9897\u7c92\u7684\u4ea7\u751f\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cCpAM\u56e0\u5e72\u6270pgRNA-Pol\u590d\u5408\u4f53\u5305\u88c5\u5165\u6838\u8863\u58f3\u5185\uff0c\u56e0\u6b64HBV RNA\u75c5\u6bd2\u6837\u9897\u7c92\u7684\u4ea7\u751f\u4e5f\u5c06\u540c\u65f6\u53d7\u5230\u6291\u5236\uff0c\u8fd9\u4e00\u73b0\u8c61\u5df2\u5728ABI-H0731\u3001GLP-26\u7b49\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u9a8c\u8bc1(\u88681)\u3002\u6b64\u5916\uff0cCpAM\u5728\u8f83\u9ad8\u6d53\u5ea6(\u4e3a\u6291\u5236pgRNA\u5305\u88c5\u6d53\u5ea6\u768410~34\u500d)\u4e5f\u53ef\u4ee5\u8bf1\u5bfc\u6210\u719f\u6838\u8863\u58f3\u7684\u89e3\u805a\uff0c\u4ece\u800c\u6291\u5236HBV\u611f\u67d3\u53cacccDNA\u7684\u4ece\u5934\u5408\u6210<strong>[30-32]<\/strong>\u3002\u4f46\u4e0e\u4e0a\u8ff0\u73b0\u8c61\u76f8\u53cd\uff0c\u5728\u4e00\u5b9a\u60c5\u51b5\u4e0b\u8bf1\u5bfc\u7ec6\u80de\u5185\u4ea7\u751f\u7684\u5b50\u4ee3\u6210\u719f\u6838\u8863\u58f3\u7684\u89e3\u805a\u751a\u81f3\u53ef\u4fc3\u8fdbcccDNA\u7684\u7ec6\u80de\u5185\u6269\u589e\u3002\u8fd9\u53ef\u80fd\u662f\u7531\u4e8eCpAM\u8bf1\u5bfc\u5b50\u4ee3\u6210\u719f\u6838\u8863\u58f3\u7684\u89e3\u805a\u53d1\u751f\u4e8e\u6838\u5b54\u6216\u6838\u5b54\u9644\u8fd1\uff0c\u4ece\u800c\u52a0\u901f\u4e86rcDNA\u5411\u7ec6\u80de\u6838\u5185\u7684\u9012\u9001\u548ccccDNA\u7684\u5408\u6210\u589e\u52a0<strong>[31]<\/strong>\u3002\u7b14\u8005\u6700\u8fd1\u7684\u7814\u7a76<strong>[33]<\/strong>\u8bc1\u5b9e\u6838\u8863\u58f3\u86cb\u767d\u7684\u8010\u836f\u7a81\u53d8\u540c\u65f6\u62b5\u6297CpAM\u6291\u5236pgRNA\u5305\u88c5\u3001DNA\u590d\u5236\u548c\u6210\u719f\u6838\u8863\u58f3\u89e3\u805a\u53cacccDNA\u4ece\u5934\u5408\u6210\u3002\u8fd9\u4e9b\u7ed3\u679c\u8fdb\u4e00\u6b65\u8bc1\u660eCpAM\u7684\u8fd9\u4e9b\u6297\u75c5\u6bd2\u4f5c\u7528\u7686\u901a\u8fc7\u7ed3\u5408\u4e8eHAP\u53e3\u888b\uff0c\u5e76\u901a\u8fc7\u4e0e\u76f8\u540c\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u4f5c\u7528\u800c\u5b9e\u73b0\u3002\u4f46\u622a\u6b62\u76ee\u524d\uff0c\u5c1a\u672a\u53d1\u73b0CpAM\u53ef\u4ee5\u964d\u4f4eHBV\u611f\u67d3\u809d\u7ec6\u80de\u5185\u75c5\u6bd2RNA\u7684\u6c34\u5e73\uff0c\u8868\u660e\u5176\u5e76\u672a\u5e72\u6270\u6838\u5fc3\u86cb\u767d\u5bf9cccDNA\u8f6c\u5f55\u548c\u75c5\u6bd2RNA\u4ee3\u8c22\u7684\u8c03\u63a7\u4f5c\u7528\u3002<\/p>\n<p class=\"f_center\"><img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/zvd405aotqu2839.jpg\" \/><\/p>\n<p id=\"15B94HF3\"><strong>4<\/strong><strong>CpAM\u6291\u5236HBeAg\u5206\u6ccc\u7684\u4f5c\u7528\u673a\u7406<\/strong><\/p>\n<p id=\"15B94HF4\">\u9664\u4e86\u6291\u5236\u75c5\u6bd2\u590d\u5236\u4e4b\u5916\uff0c\u2160\u578b\u548c\u2161\u578bCpAM\u5728\u8f83\u9ad8\u836f\u7269\u6d53\u5ea6\u4e0b(\u4e3a\u6291\u5236pgRNA\u5305\u88c5\/DNA\u590d\u5236\u6d53\u5ea6\u7684100~500\u500d)\u5747\u53ef\u964d\u4f4e\u5206\u6ccc\u7684HBeAg\u6c34\u5e73<strong>[22, 34]<\/strong>\u3002\u5982\u56fe1\u6240\u793a\uff0cHBeAg\u7531precore\u86cb\u767d\u526a\u5207\u52a0\u5de5\u800c\u6765\u3002\u5177\u4f53\u6765\u8bb2\uff0cprecore\u86cb\u767d(pre-C\uff0cp25)\u9664\u4e86\u5171\u4eabCp\u7684\u5168\u90e8\u5e8f\u5217(amino acid\uff0caa 1~183)\u5916\uff0cp25\u5728\u5176\u6c28\u57fa\u7aef\u8fd8\u72ec\u6709\u4e00\u4e2a29\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u5e8f\u5217\uff0c\u4f4d\u4e8e\u6700\u524d\u7aef\u768419\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u4e3a\u5176\u5206\u6ccc\u4fe1\u53f7\u80bd\uff0c\u53ef\u4e0e\u4fe1\u53f7\u80bd\u8bc6\u522b\u9897\u7c92\u7ed3\u5408\uff0c\u5f15\u5bfc\u5206\u5b50\u91cf\u4e3a25 kD\u7684p25\u86cb\u767d\u5230\u8fbe\u5185\u8d28\u7f51\u819c\u3002\u5728\u4fe1\u53f7\u80bd\u9176\u5207\u5272\u4fe1\u53f7\u80bd\u4e4b\u540e\uff0c\u6240\u4ea7\u751f\u7684p22\u86cb\u767d\u88ab\u8f6c\u5165\u5185\u8d28\u7f51\u8154\u3002\u5f53p22\u86cb\u767d\u5faa\u5206\u6ccc\u9014\u5f84\u62b5\u8fbe\u9ad8\u5c14\u57fa\u4f53\u5185\u65f6\uff0cfurin\u86cb\u767d\u9176\u5207\u5272\u4e0eCp\u5171\u4eab\u5e8f\u5217\u7684\u7fa7\u57fa\u7aef\u7ed3\u6784\u57df\uff0c\u6700\u7ec8\u5f62\u6210\u53ef\u5206\u6ccc\u7684p17\u86cb\u767d\u3002\u5728p17\u86cb\u767d\u7684(-10)~(-1)\u533a\u57df\uff0c(-7)\u4f4d\u534a\u80f1\u6c28\u9178(Cystine\uff0cC)\u4e0e\u7b2c61\u4f4d\u534a\u80f1\u6c28\u9178\u5f62\u6210\u5206\u5b50\u5185C(-7)-C61\u4e8c\u786b\u952e\uff0c\u968f\u540e\u8fdb\u4e00\u6b65\u5f62\u6210\u540c\u6e90\u4e8c\u805a\u4f53\u88ab\u5206\u6ccc\u81f3\u7ec6\u80de\u5916\uff0c\u5373HBeAg\u3002\u7531\u4e8e\u5206\u5b50\u5185\u4e8c\u786b\u952e\u7684\u5f62\u6210\uff0c\u4f7f\u5f97p17\u4e8c\u805a\u4f53\u4e0eCp\u4e8c\u805a\u4f53\u7ed3\u6784\u4e0d\u540c\uff0c\u4e0d\u80fd\u5305\u88c5\u4ea7\u751f\u6838\u8863\u58f3\u6837\u7ed3\u6784<strong>[36]<\/strong>\u3002\u6545\u4e0eCp\u4e0d\u540c\uff0cHBeAg\u4ee5\u53ef\u6eb6\u6027\u4e8c\u805a\u4f53\u5f62\u5f0f\u5b58\u5728\uff0c\u5e76\u88ab\u5206\u6ccc\u5230\u7ec6\u80de\u5916\u3002\u90a3\u4e48\uff0cCpAM\u53c8\u662f\u600e\u6837\u6291\u5236HBeAg\u5206\u6ccc\u7684\u5462\uff1f\u7b14\u8005\u6700\u8fd1\u7684\u7814\u7a76<strong>[33]<\/strong>\u53d1\u73b0CpAM\u5e76\u4e0d\u5f71\u54cd\u7ec6\u80de\u5185p22\u86cb\u767d\u7684\u6c34\u5e73\uff0c\u4f46\u51cf\u5c11\u7ec6\u80de\u5185p17\u3002\u8fdb\u4e00\u6b65\u5206\u6790\u53d1\u73b0\uff0c\u5e76\u975e\u6240\u6709\u7684p17\u90fd\u5f62\u6210C(-7)-C61\u5206\u5b50\u5185\u4e8c\u786b\u952e\uff0c\u670940%~50%\u7684p17\u5219\u4ee5\u8fd8\u539f\u5f62\u5f0f\u5b58\u5728\u4e8e\u7ec6\u80de\u5185\u3002\u7531\u4e8e\u8fd8\u539f\u578bp17\u7ed3\u6784\u4e0eCp\u7c7b\u4f3c\uff0c\u5728\u73af\u5883\u53d1\u751f\u6539\u53d8\u65f6\u5219\u53ef\u80fd\u5f62\u6210Cp\u6837\u4e8c\u805a\u4f53\uff0c\u5e76\u5305\u88c5\u5f62\u6210\u7a7a\u8863\u58f3<strong>[33, 37]<\/strong>\u3002\u6b64\u5916\uff0cHAP_R01\u53ef\u8bf1\u5bfc\u8fd8\u539f\u578bp17\u7ec4\u88c5\u4ea7\u751f\u975e\u6838\u8863\u58f3\u6837\u591a\u805a\u7269\uff0c\u67d0\u4e9bCpAM\u8010\u836f\u7a81\u53d8\uff0c\u5982Cp T33N\uff0c\u4e5f\u62b5\u6297\u4e86CpAM\u5bf9HBeAg\u5206\u6ccc\u7684\u6291\u5236\u4f5c\u7528<strong>[34]<\/strong>\u3002\u56e0\u6b64\uff0c\u7b14\u8005\u63a8\u6d4bCpAM\u53ef\u80fd\u7ed3\u5408\u4e8e\u8fd8\u539f\u578bp17\u4e8c\u805a\u4f53\u95f4\u7684HAP\u53e3\u888b\u8bf1\u5bfc\u7ec6\u80de\u5185\u8fd8\u539f\u578bp17\u7ec4\u88c5\u6210\u975e\u6838\u8863\u58f3\u6837\u591a\u805a\u7269\u5e76\u968f\u4e4b\u964d\u89e3\uff0c\u4ece\u800c\u6291\u5236HBeAg\u7684\u5206\u6ccc\u3002\u5f53\u7136\uff0c\u8fd9\u4e2a\u7406\u8bba\u5047\u8bf4\u8fd8\u9700\u8fdb\u4e00\u6b65\u7684\u7ed3\u6784\u751f\u7269\u5b66\u548c\u7ec6\u80de\u751f\u7269\u5316\u5b66\u5b9e\u9a8c\u7814\u7a76\u7684\u9a8c\u8bc1\u3002\u7531\u4e8e\u6291\u5236HBeAg\u5206\u6ccc\u9700\u8981\u8f83\u9ad8\u6d53\u5ea6\u7684CpAM\uff0c\u76ee\u524d\u4e3a\u6b62\u5c1a\u672a\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d1\u73b0\u5176\u53ef\u663e\u8457\u964d\u4f4e\u8840\u6e05\u4e2dHBeAg\u7684\u6c34\u5e73\u3002\u7531\u4e8eHBeAg\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u7814\u53d1\u65b0\u4e00\u4ee3\u540c\u65f6\u6709\u6548\u6291\u5236HBeAg\u5206\u6ccc\u7684\u9776\u5411Cp\/p17\u7684\u6297\u75c5\u6bd2\u836f\u7269\uff0c\u5728\u6291\u5236\u75c5\u6bd2\u590d\u5236\u7684\u540c\u65f6\u51cf\u5c11HBeAg\u7684\u5206\u6ccc\uff0c\u6216\u53ef\u540c\u65f6\u6539\u5584\u5bbf\u4e3b\u7684\u6297HBV\u514d\u75ab\u529f\u80fd\uff0c\u4fc3\u8fdb\u6162\u6027\u4e59\u578b\u809d\u708e\u7684\u529f\u80fd\u6027\u6cbb\u6108\u3002<\/p>\n<p class=\"f_center\"><img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/3ez3obglfvp2840.jpg\" \/><\/p>\n<p id=\"15B94HF6\"><strong>\u56fe1 CpAM\u5728HBV\u590d\u5236\u5468\u671f\u4e2d\u7684\u591a\u91cd\u6297\u75c5\u6bd2\u4f5c\u7528<\/strong><\/p>\n<p id=\"15B94HF7\">\u6ce8\uff1a\u2160\u578bCpAM\u8bf1\u5bfcCp\u4e8c\u805a\u4f53\u5f62\u6210\u591a\u79cd\u5f62\u6001\u7684\u975e\u8863\u58f3\u7ed3\u6784\uff0c\u5e76\u6700\u7ec8\u7ecf\u7531\u81ea\u566c\u9014\u5f84\u88ab\u964d\u89e3[35]\uff1b\u2161\u578bCpAM\u52a0\u901f\u8863\u58f3\u7ec4\u88c5\u8fc7\u7a0b\uff0c\u8bf1\u5bfc\u7a7a\u8863\u58f3\u7ed3\u6784\u4ea7\u751f\u3002\u5c31\u7ed3\u679c\u800c\u8a00\uff0c\u4e24\u79cd\u7c7b\u578b\u7684CpAM\u7686\u6291\u5236\u4e86pgRNA\/pol\u5411\u6838\u8863\u58f3\u5185\u7684\u5305\u88c5\u4ece\u800c\u6291\u5236\u540e\u7eedHBV DNA\u7684\u590d\u5236\uff1b\u4e5f\u4fc3\u8fdb\u542brcDNA\u6838\u8863\u58f3\u7684\u9519\u8bef\u89e3\u805a\u4ece\u800c\u6291\u5236\u4e86cccDNA\u7684\u4ece\u5934\u5408\u6210\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u2160\u3001\u2161\u578bCpAM\u7686\u76f4\u63a5\u4f5c\u7528\u4e8e\u7ec6\u80de\u5185\u7684p17\u4ece\u800c\u6291\u5236\u4e86HBeAg\u7684\u5206\u6ccc\u3002<\/p>\n<p id=\"15B94HF8\"><strong>5<\/strong><strong>CpAM\u4e34\u5e8a\u8bd5\u9a8c\u73b0\u72b6\u6982\u89c8<\/strong><\/p>\n<p id=\"15B94HF9\">CpAM\u4e3a\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u53d1\u9636\u6bb5\u7684\u70ed\u70b9\u65b0\u578b\u6297HBV\u836f\u7269\uff0c\u5df2\u6709\u8d85\u8fc710\u79cd\u2160\u578b\u548c\u2161\u578bCpAM\u8fdb\u5165\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u5728\u6982\u5ff5\u9a8c\u8bc1(POC)\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc1\u660e\u5176\u5177\u6709\u660e\u786e\u7684\u6297\u75c5\u6bd2\u4f5c\u7528<strong>[38]<\/strong>(\u8868 1)\u3002\u8fdb\u5165\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684CpAM\u5b58\u5728\u5355\u4e00\u6cbb\u7597\u548c\u4e0e\u5176\u4ed6\u4e0d\u540c\u4f5c\u7528\u673a\u5236\u7684\u65b0\u836f\u6216\u4e0e\u5df2\u83b7\u6279\u6297HBV\u836f\u7269\u8054\u5408\u7b49\u6a21\u5f0f\u3002\u4e0b\u9762\uff0c\u5c06\u7b80\u8ff0\u548c\u8ba8\u8bba\u51e0\u4e2a\u5177\u6709\u4ee3\u8868\u6027\u7684CpAM\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/p>\n<p id=\"15B94HFA\">NVR3-778\u662f\u7b2c\u4e00\u4e2a\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u7684CpAM\u3002\u572828 d\u7684POC\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8be5\u836f\u5355\u72ec\u6216\u4e0ePEG-IFN\u03b1-2a\u8054\u7528\u5747\u663e\u8457\u964d\u4f4eCHB\u60a3\u8005\u8840\u6e05HBV DNA\u548cHBV RNA\u6c34\u5e73\u3002\u4e14\u8054\u5408\u7528\u836f\u6291\u5236\u75c5\u6bd2\u590d\u5236\u5f3a\u5ea6\u4f18\u4e8e\u5355\u4e00\u7528\u836f<strong>[39]<\/strong>\u3002GLS4\u662f\u2160\u578bCpAM\u7684\u4ee3\u8868\u6027\u836f\u7269\uff0c\u4e0d\u4ec5\u9ad8\u6548\u5e72\u6270\u6838\u8863\u58f3\u88c5\u914d\u548c\u89e3\u805a\uff0c\u4e5f\u5bf9\u6838\u82f7\u7c7b\u836f\u7269\u8010\u836f\u7684HBV\u6709\u76f8\u540c\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u8be5\u5316\u5408\u7269\u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u4f53\u5185\u5355\u72ec\u4f7f\u7528\u65f6\u5c3d\u7ba1\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\uff0c\u4f46\u5355\u7528\u65e0\u6cd5\u7ef4\u6301\u6709\u6548\u7684\u8840\u836f\u6d53\u5ea6\u3002\u76ee\u524dGLS4\u591a\u4e0e\u5229\u6258\u4ed6\u97e6\u8054\u7528\u4ee5\u63d0\u9ad8GLS4\u7684\u8840\u836f\u6d53\u5ea6<strong>[40]<\/strong>\u3002\u5728\u4e3a\u671f28 d\u7684POC\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cGLS4\u4e0e\u5229\u6258\u4ed6\u97e6\u8054\u7528\u7ec4\u60a3\u8005\u8010\u53d7\u6027\u826f\u597d\u4e14\u8840\u6e05HBV DNA\u3001HBV RNA\u4e0b\u964d\u660e\u663e\uff0c\u540c\u65f6HBsAg\u548cHBcAg\u4e5f\u5448\u4e00\u5b9a\u5e45\u5ea6\u7684\u4e0b\u964d\u3002\u2161\u578bCpAM AB-506\u53ef\u5e7f\u6cdb\u6291\u5236A~H\u57fa\u56e0\u578bHBV\u7684\u590d\u5236\uff0c\u5e76\u6291\u5236\u6838\u82f7(\u9178)\u7c7b\u4f3c\u7269(NUC)\u8010\u836f\u7a81\u53d8\u7684HBV\u590d\u5236\u3002\u5728HBV\u9ad8\u538b\u6c34\u52a8\u529b\u5c0f\u9f20\u52a8\u7269\u5b9e\u9a8c\u4e2d\u53ef\u4f7f\u5c0f\u9f20\u8840\u6e05\u4e2dHBV DNA\u4e0b\u964d3log10\uff0c\u5728\u4e0eRNAi\u548cNUC\u8054\u7528\u65f6\u8868\u73b0\u51fa\u534f\u540c\u4f5c\u7528<strong>[41]<\/strong>\u3002\u5728\u4e3a\u671f28 d\u7684\u2160\u671f\u4e34\u5e8aPOC\u8bd5\u9a8c\u4e2d\uff0cAB-506\u5bf9\u8840\u6e05HBV DNA\u3001HBV RNA\u7684\u6291\u5236\u6700\u9ad8\u53ef\u8fbe-2.8 log10\u62f7\u8d1d\/mL\uff0c\u4e0e\u540c\u671f\u5176\u4ed6CpAM\u6297\u75c5\u6bd2\u6c34\u5e73\u76f8\u5f53<strong>[42]<\/strong>\u3002\u4f46\u7531\u4e8e\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u5065\u5eb7\u53d7\u8bd5\u8005\u4eba\u7fa4\u4e2d\u53d1\u751f2\u4f8b\u6025\u6027\u809d\u708e\uff0c\u5904\u4e8e\u5b89\u5168\u6027\u8003\u8651\u8be5\u836f\u7684\u540e\u7eed\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ec8\u6b62\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c1\u4f8b\u5728\u6cbb\u7597\u57fa\u7ebf\u53d1\u751fCp I105T\u81ea\u7136\u7a81\u53d8\u7684CHB\u60a3\u8005\u5bf9160 mg\/d\u5242\u91cf\u7684AB-506\u5448\u73b0\u65e0\u5e94\u7b54\u72b6\u6001\u3002\u4f53\u5916\u7ec6\u80de\u6297\u75c5\u6bd2\u8bd5\u9a8c\u8fdb\u4e00\u6b65\u8bc1\u5b9eCp I105T\u7a81\u53d8HBV\u5bf9AB506\u8010\u836f<strong>[43]<\/strong>\u3002\u6b64\u4e3a\u8fc4\u4eca\u4e3a\u6b62\u552f\u4e00\u62a5\u9053\u7684CpAM\u539f\u53d1\u8010\u836f\u7684\u75c5\u4f8b\u3002\u53ef\u4ee5\u9884\u89c1\uff0c\u968f\u7740CpAM\u4e34\u5e8a\u7814\u7a76\u7684\u5e7f\u6cdb\u6df1\u5165\uff0c\u66f4\u591a\u7684\u539f\u53d1\u548c\u7ee7\u53d1\u6297\u836f\u7a81\u53d8\u5c06\u88ab\u53d1\u73b0\u3002\u8fd9\u4e5f\u4e3a\u4eca\u540eCpAM\u8010\u836f\u7a81\u53d8\u673a\u7406\u7684\u7814\u7a76\uff0c\u8010\u836f\u75c5\u6bd2\u7684\u76d1\u6d4b\u9a8c\u8bc1\u548c\u5f00\u53d1\u65b0\u578b\u5177\u6709\u9ad8\u8010\u836f\u5c4f\u969c\u7684CpAM\u63d0\u51fa\u4e86\u66f4\u9ad8\u7684\u8981\u6c42\u3002<\/p>\n<p id=\"15B94HFB\">\u2161\u578bCpAM ABI-H0731\u4e3a\u8fd1\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8fdb\u6700\u5feb\u7684CpAM\u4e4b\u4e00\u3002\u5176\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u7686\u5728\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u4e86\u79ef\u6781\u53cd\u9988\uff0c\u5bf9CHB\u60a3\u8005\u8840\u6e05\u4e2dHBV DNA\u3001HBV pgRNA\u5448\u73b0\u51fa\u5f88\u597d\u7684\u6291\u5236\u6548\u5e94<strong>[44]<\/strong>\u3002\u5728NUC\u7ecf\u6cbb\u7684\u3001\u5df2\u83b7\u5f97\u6301\u7eed\u75c5\u6bd2\u5b66\u6291\u5236\u7684HBeAg\u9633\u6027\u6216\u9634\u6027CHB\u60a3\u8005\u4e2d\uff0cABI-H0731\u8054\u7528NUC\u53ef\u5e2e\u52a9NUC\u7ecf\u6cbb\u7684HBeAg\u9633\u6027\u60a3\u8005\u8840\u6e05HBV DNA\u5b9e\u73b0\u66f4\u5feb\u5730\u4e0b\u964d\u3001\u5b9e\u73b0pgRNA\u9634\u8f6c\uff0c\u4f46HBsAg\u7684\u53d8\u5316\u4e0d\u660e\u663e<strong>[45]<\/strong>\u3002\u5728\u540e\u7eed\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d1\u73b0\uff0c\u65e0\u8bba\u5728NUC\u521d\u6cbb\u4eba\u7fa4\u6216\u7ecf\u6cbb\u4eba\u7fa4\uff0c\u5c3d\u7ba1\u76f8\u6bd4\u4e8e\u5355\u72ec\u4f7f\u7528\u6069\u66ff\u5361\u97e6\uff0c\u8054\u5408\u4f7f\u7528ABI-H0371\u4e0e\u6069\u66ff\u5361\u97e6\u5448\u73b0\u51fa\u66f4\u5feb\u66f4\u663e\u8457\u7684HBV DNA\u3001HBV pgRNA\u7684\u964d\u4f4e\uff0cALT\u590d\u5e38\u7387\u660e\u663e\u5347\u9ad8<strong>[46]<\/strong>\u3002\u4f46\u5728HBeAg\u9633\u6027\u7684NUC\u672a\u6cbbCHB\u4eba\u7fa4\uff0cABI-0731\u4e0eNUC\u8054\u752872\u5468\u65f6\u4ecd\u65e0\u6cd5\u5b9e\u73b0\u6301\u7eed\u6027\u75c5\u6bd2\u5b66\u5e94\u7b54(\u8840\u6e05HBV DNA\u3001HBV RNA\u6c34\u5e73\u867d\u6301\u7eed\u4e0b\u964d\uff0c\u4f46\u4ecd\u672a\u4f4e\u4e8e\u68c0\u6d4b\u4e0b\u9650)\uff1b\u5728HBeAg\u9633\u6027\u6216\u9634\u6027\u7684NUC\u7ecf\u6cbb\u60a3\u8005\u7ec4\uff0c\u90e8\u5206\u60a3\u8005\u8840\u6e05HBV DNA\u3001HBV RNA\u6c34\u5e73\u4f4e\u4e8e\u68c0\u6d4b\u4e0b\u9650\u4e14HBeAg\u6c34\u5e73\u9634\u8f6c\u6216\u22645 IU\/mL\u65f6\u505c\u6b62\u6cbb\u7597\u89c2\u5bdf\u5176\u75c5\u6bd2\u5b66\u53cd\u5f39\u60c5\u51b5\uff0c\u7ed3\u679c\u663e\u793a\u6240\u6709\u505c\u6b62\u6cbb\u7597\u7684\u60a3\u8005\u572816\u5468\u5185\u5168\u90e8\u75c5\u6bd2\u5b66\u53cd\u5f39<strong>[47]<\/strong>\u3002\u8fd9\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u8868\u660e\uff0c\u73b0\u6709CpAM\u53ef\u663e\u8457\u964d\u4f4eCHB\u60a3\u8005\u8840\u6e05\u4e2d\u7684HBV DNA\u548cHBV RNA\uff0c\u4f46\u5e76\u672a\u663e\u8457\u5f71\u54cd\u60a3\u8005\u8840\u6e05\u4e2d\u75c5\u6bd2\u6297\u539f\u7684\u6c34\u5e73\u3002\u4e14\u591a\u6570CpAM\u5728\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u9009\u62e9\u4e0e\u73b0\u6709\u6297HBV\u836f\u7269\u8054\u5408\u7528\u836f\uff0c\u4ee5\u76d1\u6d4b\u5176\u662f\u5426\u5177\u6709\u6291\u5236HBV\u590d\u5236\u7684\u534f\u540c\u4f5c\u7528\uff0c\u4f46\u4e0e\u4e0a\u8ff0ABI-H0731\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u7c7b\u4f3c\uff0cCpAM\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u7528\u65f6\u786e\u5b9e\u5177\u6709\u66f4\u597d\u7684\u534f\u540c\u6297\u75c5\u6bd2\u4f5c\u7528\uff0c\u4f46\u505c\u836f\u540e\u5168\u90e8\u89c2\u5bdf\u5230\u75c5\u6bd2\u5b66\u53cd\u5f39\u3002<\/p>\n<p id=\"15B94HFC\"><strong>6<\/strong><strong>CpAM\u5bf9\u4fc3\u8fdbCHB\u60a3\u8005\u529f\u80fd\u6027\u6cbb\u6108\u7684\u4e34\u5e8a\u5e94\u7528\u524d\u666f<\/strong><\/p>\n<p id=\"15B94HFD\">CpAM\u56e0\u5176\u4f5c\u7528\u4e8eHBV\u590d\u5236\u548c\u6297\u539f\u5206\u6ccc\u7b49\u591a\u4e2a\u91cd\u8981\u73af\u8282\uff0c\u662f\u4e00\u7c7b\u5907\u53d7\u671f\u5f85\u7684\u65b0\u578b\u6297HBV\u836f\u7269\u3002\u7136\u800c\uff0c\u76ee\u524d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u5c3d\u7ba1\u5176\u5177\u6709\u8f83\u5f3a\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\uff0c\u80fd\u663e\u8457\u964d\u4f4e\u60a3\u8005\u8840\u6e05\u4e2dHBV DNA\u548cRNA\uff0c\u4f46\u4e0d\u663e\u8457\u6539\u53d8\u75c5\u6bd2\u86cb\u767d\u6c34\u5e73(\u8868 1)\u3002\u5c3d\u7ba1CpAM\u4e0eNUC\u8054\u7528\u53ef\u66f4\u5feb\u66f4\u5f3a\u964d\u4f4eHBV DNA\u548cRNA\uff0c\u4f46\u5bf9\u60a3\u8005\u7684\u8840\u6e05HBsAg\u6c34\u5e73\u5e76\u65e0\u663e\u8457\u5f71\u54cd\uff0c\u4e14\u505c\u6b62\u7ed9\u836f\u540e\u4ecd\u6709\u9ad8\u7684\u75c5\u6bd2\u5b66\u53cd\u5f39\uff0c\u65e0\u6cd5\u83b7\u5f97\u957f\u65f6\u95f4\u7684\u75c5\u6bd2\u5b66\u6291\u5236\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5728\u7edd\u5927\u591a\u6570\u60a3\u8005\u6709\u9650\u7597\u7a0b(1\u5e74\uff0c\u751a\u81f33\u5e74)\u7684\u5f3a\u6548\u6291\u5236HBV DNA\u590d\u5236\u5e76\u4e0d\u80fd\u8017\u7aed\u6216\u6301\u7eed\u6c89\u9ed8cccDNA\u3001\u6216\u6709\u6548\u6fc0\u6d3b\u5bbf\u4e3b\u6297\u75c5\u6bd2\u514d\u75ab\u53cd\u5e94\uff0c\u56e0\u800c\u65e0\u6cd5\u8fbe\u5230\u6301\u4e45\u63a7\u5236HBV\u611f\u67d3\u7684\u76ee\u7684\u3002\u6b64\u5916\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\u5728\u75c5\u6bd2\u590d\u5236\u88ab\u6291\u5236\u540e\uff0c\u6709\u6548\u6fc0\u6d3b\u5bbf\u4e3b\u7279\u5f02\u6027\u6297\u75c5\u6bd2\u4f53\u6db2\u548c\u7ec6\u80de\u514d\u75ab\u4e3aCHB\u529f\u80fd\u6027\u6cbb\u6108\u6240\u5fc5\u9700\u3002\u56e0\u6b64\uff0c\u4e9f\u9700\u7814\u53d1\u53ef\u9ad8\u6548\u6291\u5236cccDNA\u5408\u6210\u548cHBeAg\u5206\u6ccc\u7684\u65b0\u578bCpAM\uff0c\u5e76\u4e0e\u5176\u4ed6\u7c7b\u578b\u6297\u75c5\u6bd2\u836f\u7269(siRNA)\u548c\u514d\u75ab\u6cbb\u7597\u836f\u7269(PEG-IFN\u03b1-2a, TLR7 or TLR8\u6fc0\u52a8\u5242\uff0c\u6cbb\u7597\u6027\u75ab\u82d7\u7b49)\u8054\u5408\u6216\u5e8f\u8d2f\u6cbb\u7597\uff0c\u4ee5\u671f\u52a0\u901fcccDNA\u8017\u7aed\u3001\u964d\u4f4e\u75c5\u6bd2\u6297\u539f\u6c34\u5e73\u5e76\u6fc0\u6d3bHBV\u7279\u5f02\u6027\u6297\u75c5\u6bd2\u514d\u75ab\uff0c\u4ece\u800c\u63a7\u5236HBV\u611f\u67d3\uff0c\u5b9e\u73b0CHB\u7684\u529f\u80fd\u6027\u6cbb\u6108\u3002<\/p>\n<p id=\"15B94HFE\"><strong>\u67e5\u770b\u539f\u6587\u6216\u514d\u8d39\u4e0b\u8f7dPDF<\/strong><\/p>\n<blockquote id=\"15B94HFL\"><p>http:\/\/www.lcgdbzz.org\/cn\/article\/doi\/10.3969\/j.issn.1001-5256.2022.08.005<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<p id=\"15B94HFG\"><strong>\u5f15\u8bc1\u672c\u6587<\/strong><\/p>\n<p id=\"15B94HFH\">\u5218\u6167, \u9c81\u51e4\u6c11, \u90ed\u5de8\u6d9b. \u4e59\u578b\u809d\u708e\u75c5\u6bd2\u6838\u5fc3\u86cb\u767d\u53d8\u6784\u8c03\u8282\u5242\u7684\u4f5c\u7528\u673a\u7406\u53ca\u4e34\u5e8a\u7814\u53d1\u548c\u5e94\u7528\u524d\u666f[J]. \u4e34\u5e8a\u809d\u80c6\u75c5\u6742\u5fd7, 2022, 38(8): 1726-1732.<\/p>\n<p id=\"15B94HFI\">\u672c\u6587\u7f16\u8f91\uff1a\u738b\u83b9<\/p>\n<p id=\"15B94HFJ\">\u516c\u4f17\u53f7\u7f16\u8f91\uff1a\u90a2\u7fd4\u5b87<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HBV\u611f\u67d3\u662f\u6211\u56fd\u75c5\u6bd2\u6027\u809d\u708e\u3001\u809d\u786c\u5316\u548c\u539f\u53d1\u6027\u809d\u7ec6\u80de\u764c\u7684\u4e3b\u8981\u75c5\u56e0\u4e4b\u4e00\u3002HBV\u5728\u611f\u67d3\u809d\u7ec6\u80de\u7684\u6709\u6548\u590d\u5236\u662f\u7ef4\u6301\u75c5\u6bd2\u6301\u7eed\u611f\u67d3\u548c\u81f4\u75c5\u7684\u5fc5\u9700\u73af\u8282\u3002\u4f5c\u4e3a\u6784\u6210\u75c5\u6bd2\u6838\u8863\u58f3\u7684\u7ed3\u6784\u86cb\u767d\uff0c\u6838\u5fc3\u86cb\u767d(Cp)\u5728HBV\u590d\u5236\u5468\u671f\u7684\u591a\u4e2a\u73af\u8282\u53d1\u6325\u652f\u6301\u548c\u8c03\u63a7\u529f\u80fd\u3002\u672c\u6587\u5c06\u7cfb\u7edf\u9610\u8ff0Cp\u5728HBV\u590d\u5236\u8fc7\u7a0b\u4e2d\u7684\u529f\u80fd\u548c\u673a\u7406\uff0c\u53ca\u5728\u7814\u7684\u9776\u5411HBV Cp\u88c5\u914d\u7684\u6297HBV\u65b0\u836f\u5206\u7c7b\u3001\u4f5c\u7528\u673a\u5236\u3001\u4e34\u5e8a\u7814\u53d1\u73b0\u72b6\u53ca\u5bf9\u4e59\u578b\u809d\u708e\u529f\u80fd\u6027\u6cbb\u6108\u7684\u6f5c\u5728\u4ef7\u503c\uff0c\u4ee5\u671f\u4e3a\u8be5\u7c7b\u65b0\u836f\u7684\u7814\u53d1\u548c\u4e34\u5e8a\u8bd5\u9a8c\u63d0\u4f9b\u6307\u5bfc\u6027\u610f\u89c1\u3002 1HBV Cp\u5728\u75c5\u6bd2\u590d\u5236\u5468\u671f\u7684\u591a\u4e2a\u73af\u8282\u53d1\u6325\u91cd\u8981\u529f\u80fd \u5b8c\u6574\u7684\u6709\u611f\u67d3\u6027\u7684HBV\u4e3a\u76f4\u5f8442 nm\u7684\u7403\u5f62\u9897\u7c92\u3002\u5916\u5c42\u4e3a\u8102\u8d28\u56ca\u819c\uff0c\u67093\u79cd\u56ca\u819c\u86cb\u767d(\u5927\u3001\u4e2d\u3001\u5c0f\u8868\u9762\u6297\u539f\u86cb\u767d)\u9576\u5d4c\u5176\u4e2d\u3002\u56ca\u819c\u5185\u4e3a\u76f4\u5f84\u7ea632 nm\u7684\u6b63\u4e8c\u5341\u9762\u4f53\u6838\u8863\u58f3\u3002\u6838\u8863\u58f3\u5185\u5305\u88c5\u67093.2 kb\u7684\u90e8\u5206\u53cc\u94fe\u677e\u5f1b\u73af\u72b6DNA(rcDNA)[1]\u3002HBV\u4ec5\u611f\u67d3\u4eba\u809d\u7ec6\u80de\uff0c\u8fd9\u4e3b\u8981\u662f\u56e0\u4e3a\u809d\u7ec6\u80de\u8868\u9762\u5177\u6709HBV\u7684\u7279\u5f02\u6027\u53d7\u4f53Na+-\u725b\u78fa\u80c6\u9178\u5171\u8f6c\u8fd0\u591a\u80bd(NTCP)[2]\u3002HBV\u75c5\u6bd2\u9897\u7c92\u4e0e\u809d\u7ec6\u80de\u8868\u9762\u7684NTCP\u7ed3\u5408\uff0c\u901a\u8fc7\u5185\u541e\u9014\u5f84\u8fdb\u5165\u7ec6\u80de\u3002\u968f\u540e\u75c5\u6bd2\u56ca\u819c\u4e0e\u5185\u541e\u4f53\u819c\u878d\u5408\u5c06\u6838\u8863\u58f3\u91ca\u653e\u5165\u7ec6\u80de\u8d28\u4e2d\u3002\u6838\u8863\u58f3\u4f9d\u6b21\u88ab\u8f6c\u8fd0\u81f3\u6838\u5b54\u590d\u5408\u4f53\u5e76\u5728\u6b64\u89e3\u805a\uff0c\u5c06rcDNA\u91ca\u653e\u5165\u7ec6\u80de\u6838\uff0c\u5e76\u88ab\u4fee\u590d\u4ea7\u751f\u5171\u4ef7\u95ed\u5408\u73af\u72b6DNA (cccDNA)[3]\u3002\u8fdb\u5165\u7ec6\u80de\u6838\u5185\u7684cccDNA\u4e0e\u6838\u5c0f\u4f53\u7ed3\u5408\u5e76\u7ecf\u8fdb\u4e00\u6b65\u4fee\u9970\u5f62\u6210\u5fae\u5c0f\u67d3\u8272\u4f53, \u8f6c\u5f55\u4ea7\u751f5\u79cd\u75c5\u6bd2\u4fe1\u4f7fRNA(mRNA)\u5e76\u7ffb\u8bd1\u4ea7\u751f\u4ee5\u4e0b7\u79cd\u75c5\u6bd2\u86cb\u767d\uff1a3.5 kb pre-C RNA\uff0c\u5176\u7ffb\u8bd1\u4ea7\u751fprecore\u86cb\u767d\uff0c\u8be5\u86cb\u767d\u7ecf\u540e\u7eed\u5207\u5272\u52a0\u5de5\u6700\u7ec8\u6210\u719f\u4e3aHBeAg\u800c\u88ab\u5206\u6ccc\u81f3\u7ec6\u80de\u5916\uff1b\u542b\u4e24\u4e2a\u5f00\u653e\u9605\u8bfb\u6846\u67b6\u76843.5 kb pregenomic&#8230;<\/p>\n","protected":false},"author":1,"featured_media":578,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[565,18,567,466,566],"class_list":["post-631","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tech","tag-565","tag-18","tag-567","tag-466","tag-566"],"featured_image_urls":{"full":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483.jpg",307,400,false],"thumbnail":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483-150x150.jpg",150,150,true],"medium":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483-230x300.jpg",230,300,true],"medium_large":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483.jpg",307,400,false],"large":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483.jpg",307,400,false],"1536x1536":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483.jpg",307,400,false],"2048x2048":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483.jpg",307,400,false],"covernews-slider-full":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483.jpg",307,400,false],"covernews-slider-center":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483.jpg",307,400,false],"covernews-featured":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483.jpg",307,400,false],"covernews-medium":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483-307x340.jpg",307,340,true],"covernews-medium-square":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6dacc4483-307x250.jpg",307,250,true]},"author_info":{"display_name":"admin","author_link":"https:\/\/demo3.aiwalls.com\/cn-news\/?author=1"},"category_info":"<a 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