{"id":613,"date":"2022-09-11T13:20:39","date_gmt":"2022-09-11T05:20:39","guid":{"rendered":"http:\/\/demo3.aiwalls.com\/cn-news\/index.php\/2022\/09\/11\/%e5%8f%91%e7%8e%b0%e5%8f%a6%e7%b1%bb%e8%9b%8b%e7%99%bd%ef%bc%8c%e7%a7%91%e5%ad%a6%e5%ae%b6%e6%89%93%e5%bc%80%e9%a3%9e%e8%9d%97%e9%a3%9e%e8%a1%8c%e6%9c%89%e6%b0%a7%e4%bb%a3%e8%b0%a2%e7%aa%8d%e9%97%a8\/"},"modified":"2022-09-11T13:20:39","modified_gmt":"2022-09-11T05:20:39","slug":"%e5%8f%91%e7%8e%b0%e5%8f%a6%e7%b1%bb%e8%9b%8b%e7%99%bd%ef%bc%8c%e7%a7%91%e5%ad%a6%e5%ae%b6%e6%89%93%e5%bc%80%e9%a3%9e%e8%9d%97%e9%a3%9e%e8%a1%8c%e6%9c%89%e6%b0%a7%e4%bb%a3%e8%b0%a2%e7%aa%8d%e9%97%a8","status":"publish","type":"post","link":"https:\/\/demo3.aiwalls.com\/cn-news\/?p=613","title":{"rendered":"\u53d1\u73b0\u53e6\u7c7b\u86cb\u767d\uff0c\u79d1\u5b66\u5bb6\u6253\u5f00\u98de\u8757\u98de\u884c\u6709\u6c27\u4ee3\u8c22\u7a8d\u95e8"},"content":{"rendered":"<p class=\"f_center\"> <img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/jpzdjmlku1l2877.jpg\" \/><\/p>\n<p id=\"157TBF4R\"> \u98de\u8757\u3002\u53d7\u8bbf\u8005\u4f9b\u56fe<\/p>\n<p id=\"157TBF4U\">\u6c27\u6c14\u5bf9\u4e8e\u51e0\u4e4e\u6240\u6709\u52a8\u7269\u7684\u751f\u547d\u6d3b\u52a8\u90fd\u81f3\u5173\u91cd\u8981\u3002\u52a8\u7269\u5df2\u7ecf\u8fdb\u5316\u51fa\u590d\u6742\u7684\u547c\u5438\u7cfb\u7edf\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u5c06\u6c27\u6c14\u8f93\u9001\u5230\u8eab\u4f53\u7684\u6bcf\u4e2a\u90e8\u4f4d\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5f53\u65b0\u9648\u4ee3\u8c22\u9700\u6c42\u8d85\u8fc7\u4f9b\u5e94\u65f6\uff0c\u5076\u5c14\u4f1a\u53d1\u751f\u6c27\u6c14\u77ed\u7f3a\u3002<\/p>\n<p id=\"157TBF51\">\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff08Hif\uff09\u88ab\u8ba4\u4e3a\u662f\u751f\u7269\u4f53\u4e2d\u5e2e\u52a9\u7ec6\u80de\u9002\u5e94\u4f4e\u6c27\u73af\u5883\u7684\u6838\u5fc3\u86cb\u767d\u3002\u7136\u800c\uff0c\u6700\u8fd1\u4e2d\u56fd\u79d1\u5b66\u9662\u52a8\u7269\u7814\u7a76\u6240\u7814\u7a76\u5458\u5eb7\u4e50\u9662\u58eb\u56e2\u961f\u5728\u7814\u7a76\u98de\u8757\u98de\u884c\u8fc7\u7a0b\u65f6\u610f\u5916\u53d1\u73b0\uff0cHif\u5bb6\u65cf\u4e2d\u6709\u4e00\u4e2a\u53e6\u7c7b\u6210\u5458\uff0c\u5b83\u4e0d\u4ec5\u4e0d\u53c2\u4e0e\u4f4e\u6c27\u54cd\u5e94\uff0c\u53cd\u800c\u5728\u6b63\u5e38\u6c27\u91cf\u73af\u5883\u4e0b\u6709\u5f88\u6d3b\u8dc3\u7684\u53cd\u5e94\u3002<\/p>\n<p id=\"157TBF54\">\u7814\u7a76\u4eba\u5458\u5c06\u8fd9\u79cd\u7279\u6b8a\u7684\u86cb\u767d\u547d\u540d\u4e3aHif-1\u03b12\uff0c\u8ba4\u4e3a\u5b83\u5bf9\u8757\u866b\u5b9e\u73b0\u957f\u65f6\u95f4\u98de\u884c\u81f3\u5173\u91cd\u8981\u30028\u670830\u65e5\uff0c\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728\u56fd\u9645\u751f\u7269\u5b66\u671f\u520aeLife\u4e0a\uff0c\u5e76\u88ab\u4f5c\u4e3a\u4eae\u70b9\u6587\u7ae0\u63a8\u8350\u3002<\/p>\n<p id=\"157TBF57\"><strong>\u53cd\u5e38\u4e0e\u56f0\u60d1<\/strong><\/p>\n<p id=\"157TBF5A\">\u5728\u6c27\u6c14\u7f3a\u4e4f\u65f6\uff0c\u4f1a\u53d1\u751f\u600e\u6837\u7684\u751f\u7406\u53d8\u5316\u548c\u4ee3\u8c22\u53cd\u5e94\uff1f\u957f\u671f\u4ee5\u6765\uff0c\u5f88\u591a\u79d1\u5b66\u5bb6\u5bf9\u52a8\u7269\u7ec6\u80de\u611f\u77e5\u6c27\u6c14\u53d8\u5316\u7684\u5206\u5b50\u5f00\u5173\u8fdb\u884c\u4e86\u5927\u91cf\u7814\u7a76\u3002<\/p>\n<p id=\"157TBF5D\">1991\u5e74\u4eba\u4eec\u53d1\u73b0\u4e00\u79cd\u7279\u5b9a\u7684DNA-\u86cb\u767d\u8d28\u590d\u5408\u7269\uff0c\u5176\u4f1a\u968f\u7740\u6c27\u6c14\u6d53\u5ea6\u7684\u53d8\u5316\u53d1\u751f\u76f8\u5e94\u7684\u6539\u53d8\uff0c\u8fd9\u4e2a\u86cb\u767d\u8d28\u88ab\u547d\u540d\u4e3a\u201c\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u201d\uff08Hif\uff09\u3002<\/p>\n<p id=\"157TBF5G\">2019\u5e74\uff0c\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u9881\u53d1\u7ed9\u4e86\u4e24\u4f4d\u7f8e\u56fd\u548c\u4e00\u4f4d\u82f1\u56fd\u79d1\u5b66\u5bb6\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u5728Hif\u7684\u53d1\u73b0\u53ca\u5176\u8c03\u8282\u4f4e\u6c27\u9002\u5e94\u7684\u529f\u80fd\u3002\u540c\u65f6\uff0c\u8fd9\u4e2a\u53d1\u73b0\u4e5f\u4e3a\u8d2b\u8840\u3001\u764c\u75c7\u548c\u8bb8\u591a\u5176\u4ed6\u75be\u75c5\u5f15\u8d77\u7684\u5c40\u90e8\u7f3a\u6c27\u7684\u7814\u7a76\u548c\u6cbb\u7597\u63d0\u4f9b\u6709\u7528\u7684\u7ebf\u7d22\u548c\u65b0\u7684\u6cbb\u7597\u601d\u8def\u3002<\/p>\n<p id=\"157TBF5J\">\u57fa\u4e8e\u524d\u671f\u7684\u7814\u7a76\u79ef\u7d2f\uff0c\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\uff0c\u53ea\u6709\u5f53\u751f\u7269\u4f53\u5904\u4e8e\u7f3a\u6c27\u73af\u5883\uff0c\u6216\u7ec4\u7ec7\u548c\u7ec6\u80de\u7b49\u5904\u4e8e\u7f3a\u6c27\u5fae\u73af\u5883\u65f6\uff0cHif\u901a\u8def\u624d\u80fd\u88ab\u6fc0\u6d3b\uff0c\u800c\u5728\u6b63\u5e38\u6c27\u542b\u91cf\u4e0bHif\u901a\u8def\u5904\u4e8e\u6291\u5236\u72b6\u6001\u3002<\/p>\n<p id=\"157TBF5M\">\u56db\u5e74\u524d\uff0c\u5eb7\u4e50\u56e2\u961f\u5e74\u8f7b\u4eba\u3001\u6b64\u6b21\u8bba\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u4e01\u738e\u5728\u897f\u85cf\u9ad8\u6d77\u62d4\u5730\u533a\uff0c\u7528\u5206\u5b50\u751f\u7269\u5b66\u624b\u6bb5\u7814\u7a76\u98de\u8757\u4f4e\u6c27\u9002\u5e94\u95ee\u9898\u7684\uff0c\u4e0e\u6240\u6709\u7814\u7a76\u4f4e\u6c27\u9002\u5e94\u95ee\u9898\u7684\u79d1\u5b66\u5bb6\u4e00\u6837\uff0cHif\u662f\u4ed6\u7814\u7a76\u4e2d\u7ed5\u4e0d\u5f00\u7684\u86cb\u767d\u8d28\u3002<\/p>\n<p id=\"157TBF5P\">\u98de\u8757\u662f\u4e00\u79cd\u6bcf\u5929\u53ef\u4ee5\u98de\u884c\u6570\u767e\u516c\u91cc\u7684\u519c\u4e1a\u5bb3\u866b\u3002\u957f\u9014\u98de\u884c\u65f6\uff0c\u98de\u8757\u6d88\u8017\u7684\u6c27\u6c14\u662f\u4f11\u606f\u65f6\u7684 30-150 \u500d\u3002\u5bf9\u4e8e\u5f88\u591a\u6606\u866b\u751f\u7269\u5b66\u7814\u7a76\u7684\u5b9e\u9a8c\u5ba4\u6765\u8bf4\uff0c\u679c\u8747\u662f\u6700\u57fa\u7840\u7684\u6a21\u5f0f\u6606\u866b\uff0c\u4f46\u8fd9\u4e2a\u5b9e\u9a8c\u56e2\u961f\u5374\u4e0d\u540c\uff0c\u4ed6\u4eec\u662f\u5168\u7403\u4ec5\u6709\u7684\u3001\u4ee5\u98de\u8757\u4f5c\u4e3a\u6a21\u5f0f\u6606\u866b\u7684\u5b9e\u9a8c\u56e2\u961f\u3002<\/p>\n<p id=\"157TBF5S\">\u4ed6\u4eec\u5148\u8ba9\u98de\u8757\u98de\u884c\u4e00\u6bb5\u65f6\u95f4\uff0c\u7136\u540e\u53d6\u4e0b\u98de\u8757\u7684\u98de\u884c\u808c\u8089\u7ec4\u7ec7\u505a\u86cb\u767d\u8d28\u5206\u6790\u3002\u5728\u98de\u8757\u7684\u98de\u884c\u808c\u4e2d\uff0c\u4ed6\u4eec\u51fa\u73b0\u4e86\u4e24\u79cd\u4e0d\u540c\u7684Hif\u86cb\u767d\u3002\u4e8e\u662f\uff0c\u4ed6\u4eec\u53c8\u5728\u7ec6\u80de\u5c42\u9762\u5206\u522b\u7814\u7a76\u8fd9\u4e24\u79cd\u86cb\u767d\u7684\u6d3b\u6027\u3002\u5f88\u5feb\uff0c\u4e00\u4e2a\u5947\u5f02\u7684\u73b0\u8c61\u5f15\u53d1\u4e86\u4e01\u738e\u7684\u6ce8\u610f\uff1a\u4e00\u79cdHif\u86cb\u767d\u53ea\u5728\u7f3a\u6c27\u65f6\u4e2d\u51fa\u73b0\uff0c\u800c\u53e6\u4e00\u79cdHif\u86cb\u767d\u5374\u53ef\u4ee5\u5728\u6709\u6c27\u73af\u5883\u4e0b\u7a33\u5b9a\u5b58\u5728\u3002\u800c\u4e14\uff0c\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0c\u98de\u8757\u5728\u5e38\u6c27\u60c5\u51b5\u4e0b\u98de\u884c\u65f6\uff0c\u98de\u884c\u808c\u4e2d\u8fd9\u79cd\u65b0\u7684\u86cb\u767d\u4f1a\u6025\u5267\u4e0a\u5347\u3002<\/p>\n<p id=\"157TBF5V\">\u201cHif\u901a\u8def\u4e0d\u662f\u53ea\u6709\u5728\u4f4e\u6c27\u73af\u5883\u4e0b\u624d\u4f1a\u88ab\u6fc0\u6d3b\u5417\uff1f\u201d\u4e01\u738e\u6709\u4e9b\u56f0\u60d1\u3002<\/p>\n<p id=\"157TBF62\">\u4ed6\u8054\u60f3\u5230\u4e86\u4ed6\u4eec\u6b64\u524d\u7684\u53e6\u4e00\u9879\u7814\u7a76\u6210\u679c\u3002\u90a3\u4e2a\u6210\u679c\u53d1\u73b0\uff0c\u7fa4\u5c45\u578b\u98de\u8757\u4e4b\u6240\u4ee5\u80fd\u591f\u8fdb\u884c\u957f\u8ddd\u79bb\u8fc1\u98de\uff0c\u5f97\u76ca\u4e8e\u5176\u5728\u98de\u884c\u8fc7\u7a0b\u4e2d\u80fd\u591f\u66f4\u597d\u5730\u7ef4\u6301\u4ee3\u8c22\u7a33\u6001\u3002<\/p>\n<p id=\"157TBF65\">\u4e01\u738e\u6000\u7591\uff1a\u201c\u65b0\u7684\u86cb\u767d\u4f1a\u4e0d\u4f1a\u662f\u98de\u8757\u98de\u884c\u4e2d\u4ee3\u8c22\u7a33\u6001\u5f97\u4ee5\u7ef4\u6301\u7684\u539f\u56e0\uff1f\u201d<\/p>\n<p id=\"157TBF68\">\u4e00\u7cfb\u5217\u95ee\u9898\u6fc0\u8d77\u4e86\u4ed6\u548c\u7814\u7a76\u56e2\u961f\u7ee7\u7eed\u6df1\u6316\u4e0b\u53bb\u7684\u5174\u8da3\u3002<\/p>\n<p id=\"157TBF6B\"><strong>\u6709\u7f3a\u53e3\u7684\u53e6\u7c7b\u86cb\u767d<\/strong><\/p>\n<p id=\"157TBF6E\">\u4ed6\u4eec\u5206\u6790\u4e86\u4e24\u79cd\u6027\u8d28\u8868\u73b0\u4e0d\u540c\u7684\u86cb\u767d\u540e\u53d1\u73b0\uff0c\u53ef\u4ee5\u5728\u5e38\u6c27\u60c5\u51b5\u4e0b\u7a33\u5b9a\u5b58\u5728\u7684Hif\u86cb\u767d\u5bf9\u5e94\u7684\u57fa\u56e0\u6709\u4e00\u5757\u201c\u7f3a\u53e3\u201d\u3002<\/p>\n<p id=\"157TBF6H\">Hif\u86cb\u767d\u542b\u6709\u4e24\u4e2a\u4e9a\u57fa\uff0c\u03b1\u4e9a\u57fa\u548c\u03b2\u4e9a\u57fa\uff0c\u5176\u4e2d\u4f4e\u6c27\u611f\u77e5\u4e9a\u57fa\u4e3a\u03b1\u4e9a\u57fa\uff0c\u88ab\u79d1\u5b66\u5bb6\u79f0\u4e3a\u201cHif-1\u03b1\u201d\u3002 Hif-1\u03b1\u6709\u4e24\u4e2a\u53cd\u5f0f\u6fc0\u6d3b\u533a\uff08TAD\uff09\uff0c\u5373N-TAD\u548cC-TAD\uff0cC-TAD\u80fd\u53d1\u6325\u7cbe\u7ec6\u8c03\u6574\u4f5c\u7528\uff0cN-TAD\u5219\u4e3a\u6fc0\u6d3b\u8f6c\u5f55\u6240\u5fc5\u9700\u3002<\/p>\n<p id=\"157TBF6K\">\u4e0e\u5e38\u89c4Hif-1\u03b1\u4e0d\u540c\u7684\u662f\uff0c\u65b0\u53d1\u73b0\u7684\u86cb\u767d\u7f3a\u5931\u4e86C-TAD\u3002\u79d1\u7814\u56e2\u961f\u5b9e\u9a8c\u53d1\u73b0\uff0c\u6b63\u662f\u7531\u4e8e\u8be5\u7ed3\u6784\u57df\u7684\u7f3a\u5931\uff0c\u4f7f\u65b0\u86cb\u767d\u80fd\u591f\u5728\u6b63\u5e38\u6c27\u73af\u5883\u4e0b\u7ef4\u6301\u8f83\u9ad8\u7684\u6d3b\u6027\u3002<\/p>\n<p id=\"157TBF6N\">\u4e8e\u662f\uff0c\u4ed6\u4eec\u628a\u8fd9\u79cd\u65b0\u7684\u86cb\u767d\u547d\u540d\u4e3a\u201cHif-1\u03b12\u201d\uff0c\u5c06\u539f\u5148\u7684Hif-1\u03b1\u79f0\u4e3a\u201cHif-1\u03b11\u201d\u3002<\/p>\n<p id=\"157TBF6Q\">\u901a\u8fc7\u5927\u91cf\u5b9e\u9a8c\uff0c\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0cHif-1\u03b12\u4f1a\u76f4\u63a5\u8f6c\u5f55\u6fc0\u6d3b\u9776\u6807\u57fa\u56e0DJ-1\u7684\u8868\u8fbe\u3002DJ-1\u6240\u7f16\u7801\u7684\u86cb\u767d\u5728\u52a8\u7269\u4f53\u5185\u662f\u4e00\u4e2a\u5173\u952e\u7684\u89e3\u6bd2\u548c\u6297\u6c27\u5316\u9176\uff0c\u53ef\u4ee5\u6709\u6548\u6e05\u9664\u98de\u8757\u98de\u884c\u65f6\u98de\u884c\u808c\u4e2d\u79ef\u7d2f\u7684\u6d3b\u6027\u6c27\u548c\u5176\u4ed6\u6709\u5bb3\u4ee3\u8c22\u4ea7\u7269\u3002<\/p>\n<p id=\"157TBF6T\">\u201c\u4e0e\u5176\u4ed6\u6606\u866b\u4e0d\u4e00\u6837\uff0c\u98de\u8757\u7279\u522b\u80fd\u98de\uff0c\u4e00\u6b21\u80fd\u98de\u4e0a\u767e\u516c\u91cc\u3002\u98de\u8757\u5728\u957f\u8ddd\u79bb\u98de\u884c\u65f6\uff0c\u4f1a\u4ea7\u751f\u5927\u91cf\u7684\u6709\u5bb3\u7269\u3002\u800cHif-1\u03b12\u53d7\u6c27\u7684\u6fc0\u6d3b\u6765\u8c03\u8282DJ-1\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u907f\u514d\u6709\u5bb3\u4ee3\u8c22\u7269\u7684\u79ef\u7d2f\uff0c\u4f7f\u98de\u8757\u80fd\u591f\u9002\u5e94\u957f\u65f6\u95f4\u7684\u6709\u6c27\u4ee3\u8c22\u8fc7\u7a0b\u3002\u201d\u8bba\u6587\u901a\u8baf\u4f5c\u8005\u5eb7\u4e50\u8bf4\u3002<\/p>\n<p id=\"157TBF70\">\u66f4\u91cd\u8981\u7684\u662f\uff0c\u7ed3\u6784\u7c7b\u4f3c\u4e8e\u98de\u8757Hif-1\u03b12\u7c7b\u578b\u7684Hif\u86cb\u767d\uff0c\u4e5f\u5b58\u5728\u4e8e\u5176\u4ed6\u52a8\u7269\u4e2d\uff0c\u7279\u522b\u662f\u4eba\u7c7b\u548c\u9e1f\u7c7b\uff0c\u4f46\u662f\u8fd9\u79cd\u5728\u5e38\u6c27\u4e0b\u80fd\u591f\u4fdd\u6301\u7a33\u5b9a\u7684Hif\u86cb\u767d\u7684\u751f\u7269\u5b66\u529f\u80fd\u5728\u6b64\u4e4b\u524d\u4e00\u76f4\u4e0d\u6e05\u695a\u3002<\/p>\n<p id=\"157TBF73\">\u201c\u672c\u7814\u7a76\u7684\u610f\u4e49\u5728\u4e8e\u6269\u5c55\u4e86\u4eba\u4eec\u5bf9\u52a8\u7269\u754c\u4e2d\u6700\u6838\u5fc3\u7684\u6c27\u6c14\u611f\u77e5\u901a\u8def\u2014\u2014Hif\u901a\u8def\u529f\u80fd\u7684\u8ba4\u8bc6\u3002\u8fd9\u4e2a\u53d1\u73b0\u8868\u660e\uff0c\u5728\u751f\u7269\u4f53\u4e2dHif\u901a\u8def\u4e0d\u4ec5\u4ec5\u8c03\u63a7\u4f4e\u6c27\u54cd\u5e94\uff0c\u540c\u65f6\u5728\u9700\u6c27\u578b\u751f\u7406\u8fc7\u7a0b\u4e2d\u4e5f\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u201d\u5eb7\u4e50\u8bf4\u3002<\/p>\n<p id=\"157TBF76\"><strong>\u201c\u6211\u4eec\u7ecf\u5f97\u4f4f\u540c\u884c\u68c0\u9a8c\u201d<\/strong><\/p>\n<p id=\"157TBF79\">\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\uff0c\u7814\u7a76\u56e2\u961f\u539f\u5148\u7684\u56f0\u60d1\u88ab\u4e00\u4e00\u63ed\u5f00\u3002\u4ed6\u4eec\u628a\u7814\u7a76\u8bba\u6587\u6295\u7ed9\u4e86\u56fd\u9645\u751f\u7269\u5b66\u671f\u520aeLife\u3002<\/p>\n<p id=\"157TBF7C\">\u5eb7\u4e50\u4ecb\u7ecd\uff0c\u5f53\u65f6\uff0c\u8fd9\u672c\u6742\u5fd7\u6709\u4e00\u4e2a\u4e0d\u6210\u6587\u7684\u89c4\u5b9a\uff0c\u5373\u5728\u5c06\u8bba\u6587\u9001\u5916\u5ba1\u65f6\uff0c\u7f16\u8f91\u4f1a\u8be2\u95ee\u4f5c\u8005\u662f\u5426\u613f\u610f\u5728\u9884\u5370\u672c\u5e73\u53f0BioRxiv\u4e0a\u516c\u5f00\u8bba\u6587\u6210\u679c\uff0c\u53ea\u6709\u4f5c\u8005\u786e\u8ba4\u540c\u610f\u516c\u5f00\u540e\uff0c\u7f16\u8f91\u624d\u4f1a\u5c06\u8bba\u6587\u9001\u5916\u5ba1\u3002<\/p>\n<p id=\"157TBF7F\">\u5eb7\u4e50\u544a\u8bc9\u300a\u4e2d\u56fd\u79d1\u5b66\u62a5\u300b\uff0c\u8bba\u6587\u5728\u9884\u5370\u672c\u5e73\u53f0\u4e0a\u7559\u6709\u8ba8\u8bba\u680f\uff0c\u5185\u5bb9\u4e5f\u53ef\u4ee5\u4f9b\u7f16\u8f91\u53c2\u8003\uff0c\u800c\u4e14\uff0c\u9884\u5370\u672c\u5e73\u53f0\u53d1\u51fa\u6765\u4e4b\u540e\uff0c\u88ab\u5176\u4ed6\u505a\u76f8\u540c\u7814\u7a76\u7684\u540c\u884c\u770b\u5230\u4e4b\u540e\uff0c\u540c\u884c\u53ef\u80fd\u4f1a\u505c\u6b62\u4ed6\u4eec\u7684\u7814\u7a76\uff0c\u5982\u6b64\u4e00\u6765\uff0c\u5982\u679c\u6700\u540e\u8bba\u6587\u7ecf\u8fc7\u5916\u5ba1\u6b63\u5f0f\u520a\u53d1\uff0c\u8bba\u6587\u5c31\u53ef\u4ee5\u83b7\u5f97\u66f4\u9ad8\u7684\u5f15\u7528\u7387\uff0c\u5bf9\u671f\u520a\u5f71\u54cd\u56e0\u5b50\u4e5f\u5e26\u6765\u6b63\u9762\u5f71\u54cd\u3002<\/p>\n<p id=\"157TBF7I\">\u800c\u5bf9\u4e8e\u6295\u7a3f\u8005\u6765\u8bf4\uff0c\u8fd9\u6837\u505a\u662f\u6709\u98ce\u9669\u7684\u3002\u201c\u5047\u5982\u88ab\u62d2\u7a3f\u4e86\uff0c\u5c31\u4f1a\u975e\u5e38\u88ab\u52a8\u3002\u201d\u5eb7\u4e50\u8bf4\u3002<\/p>\n<p id=\"157TBF7L\">\u4f46\u662f\uff0c\u5728\u6536\u5230\u7f16\u8f91\u8be2\u95ee\u662f\u5426\u5728\u9884\u5370\u672c\u4e0a\u63d0\u524d\u516c\u5f00\u7684\u90ae\u4ef6\u540e\uff0c\u5eb7\u4e50\u5374\u6b23\u7136\u540c\u610f\uff1a\u201c\u6211\u4eec\u7ecf\u5f97\u4f4f\u540c\u884c\u68c0\u9a8c\u3002\u201d<\/p>\n<p id=\"157TBF7O\">\u6700\u540e\uff0ceLife\u7684\u4e09\u4f4d\u8bc4\u5ba1\u4eba\u5168\u90e8\u540c\u610f\u53d1\u8868\u3002\u4e3a\u6b64\uff0ceLife\u8fd8\u9080\u8bf7\u4e13\u5bb6\u4e3a\u8bba\u6587\u64b0\u5199\u4e86\u8bc4\u8ff0\u6587\u7ae0\u3002<\/p>\n<p id=\"157TBF7R\">\u56fd\u9645\u4e0a\u540c\u9886\u57df\u7684\u8457\u540d\u6559\u6388Jiwon Shim\u5728\u4e13\u8bc4\u6587\u7ae0\u4e2d\u6307\u51fa\uff0c\u8fd9\u9879\u7814\u7a76\u63ed\u793a\u4e86\u53ef\u53d8\u526a\u5207\u7684Hif\u7684\u65b0\u529f\u80fd\u3002<\/p>\n<p id=\"157TBF7U\">\u201c\u6606\u866b\u662f\u6700\u65e9\u80fd\u591f\u98de\u884c\u7684\u52a8\u7269\uff0c\u4e5f\u8bb8\u6b63\u662f\u7531\u4e8e\u5728\u957f\u671f\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684Hif\u57fa\u56e0\u7ed3\u6784\u7684\u591a\u6837\u6027\uff0c\u4ee5\u53ca\u5728\u4e00\u4e9b\u79cd\u7c7b\u6606\u866b\u4e2d\u8fd9\u79cd\u4e0d\u4f9d\u8d56\u4e8e\u4f4e\u6c27\u7684Hif\u86cb\u767d\u7684\u51fa\u73b0\uff0c\u4fc3\u6210\u4e86\u73b0\u5728\u6606\u866b\u98de\u884c\u80fd\u529b\u548c\u65b9\u5f0f\u7684\u591a\u6837\u6027\u3002\u8fd9\u9879\u53d1\u73b0\u4e5f\u4e3a\u4e00\u4e9b\u9700\u8981\u7279\u5b9aHif\u86cb\u767d\u53c2\u4e0e\u7684\u751f\u7269\u5b66\u8fc7\u7a0b\uff0c\u5982\u52a8\u7269\u80da\u80ce\u53d1\u80b2\u548c\u67d0\u4e9b\u80bf\u7624\u5f62\u6210\u7b49\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u91cd\u8981\u4f9d\u636e\u548c\u7ebf\u7d22\u3002\u201dShim\u8bf4\u3002<\/p>\n<p id=\"157TBF81\">\u5eb7\u4e50\u8868\u793a\uff0c\u4e0b\u4e00\u6b65\uff0c\u7814\u7a76\u56e2\u961f\u8fd8\u5c06\u4e00\u65b9\u9762\u6a2a\u5411\u7814\u7a76Hif-1\u03b12\u5728\u5176\u4ed6\u751f\u7269\u4e2d\u7684\u5b58\u5728\u60c5\u51b5\uff0c\u53e6\u4e00\u65b9\u9762\u7eb5\u5411\u7814\u7a76\u8be5\u86cb\u767d\u7684\u4ea7\u751f\u548c\u6d3b\u6027\u8c03\u8282\u673a\u5236\u3002<\/p>\n<p class=\"f_center\"> <img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/b52f2uxiyg42878.jpg\" \/><\/p>\n<p id=\"157TBF87\">Hif-1\u03b12\u86cb\u767d\u7684\u7279\u5f81\u53ca\u5176\u4f5c\u7528\u539f\u7406\u3002\u53d7\u8bbf\u8005\u4f9b\u56fe<\/p>\n<p id=\"157TBF8A\">\u8bba\u6587\u76f8\u5173\u4fe1\u606f\uff1a<\/p>\n<p id=\"157TBF8D\">https:\/\/doi.org\/10.7554\/eLife.74554<\/p>\n<p id=\"157TBF8G\">https:\/\/doi.org\/10.7554\/eLife.82028<\/p>\n<p id=\"157TBF8J\">https:\/\/doi.org\/10.1038\/s41467-018-07529-8<\/p>\n<p id=\"157TBF8M\">\u6765\u6e90\uff1a\u4e2d\u56fd\u79d1\u5b66\u62a5<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u98de\u8757\u3002\u53d7\u8bbf\u8005\u4f9b\u56fe \u6c27\u6c14\u5bf9\u4e8e\u51e0\u4e4e\u6240\u6709\u52a8\u7269\u7684\u751f\u547d\u6d3b\u52a8\u90fd\u81f3\u5173\u91cd\u8981\u3002\u52a8\u7269\u5df2\u7ecf\u8fdb\u5316\u51fa\u590d\u6742\u7684\u547c\u5438\u7cfb\u7edf\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u5c06\u6c27\u6c14\u8f93\u9001\u5230\u8eab\u4f53\u7684\u6bcf\u4e2a\u90e8\u4f4d\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5f53\u65b0\u9648\u4ee3\u8c22\u9700\u6c42\u8d85\u8fc7\u4f9b\u5e94\u65f6\uff0c\u5076\u5c14\u4f1a\u53d1\u751f\u6c27\u6c14\u77ed\u7f3a\u3002 \u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff08Hif\uff09\u88ab\u8ba4\u4e3a\u662f\u751f\u7269\u4f53\u4e2d\u5e2e\u52a9\u7ec6\u80de\u9002\u5e94\u4f4e\u6c27\u73af\u5883\u7684\u6838\u5fc3\u86cb\u767d\u3002\u7136\u800c\uff0c\u6700\u8fd1\u4e2d\u56fd\u79d1\u5b66\u9662\u52a8\u7269\u7814\u7a76\u6240\u7814\u7a76\u5458\u5eb7\u4e50\u9662\u58eb\u56e2\u961f\u5728\u7814\u7a76\u98de\u8757\u98de\u884c\u8fc7\u7a0b\u65f6\u610f\u5916\u53d1\u73b0\uff0cHif\u5bb6\u65cf\u4e2d\u6709\u4e00\u4e2a\u53e6\u7c7b\u6210\u5458\uff0c\u5b83\u4e0d\u4ec5\u4e0d\u53c2\u4e0e\u4f4e\u6c27\u54cd\u5e94\uff0c\u53cd\u800c\u5728\u6b63\u5e38\u6c27\u91cf\u73af\u5883\u4e0b\u6709\u5f88\u6d3b\u8dc3\u7684\u53cd\u5e94\u3002 \u7814\u7a76\u4eba\u5458\u5c06\u8fd9\u79cd\u7279\u6b8a\u7684\u86cb\u767d\u547d\u540d\u4e3aHif-1\u03b12\uff0c\u8ba4\u4e3a\u5b83\u5bf9\u8757\u866b\u5b9e\u73b0\u957f\u65f6\u95f4\u98de\u884c\u81f3\u5173\u91cd\u8981\u30028\u670830\u65e5\uff0c\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728\u56fd\u9645\u751f\u7269\u5b66\u671f\u520aeLife\u4e0a\uff0c\u5e76\u88ab\u4f5c\u4e3a\u4eae\u70b9\u6587\u7ae0\u63a8\u8350\u3002 \u53cd\u5e38\u4e0e\u56f0\u60d1 \u5728\u6c27\u6c14\u7f3a\u4e4f\u65f6\uff0c\u4f1a\u53d1\u751f\u600e\u6837\u7684\u751f\u7406\u53d8\u5316\u548c\u4ee3\u8c22\u53cd\u5e94\uff1f\u957f\u671f\u4ee5\u6765\uff0c\u5f88\u591a\u79d1\u5b66\u5bb6\u5bf9\u52a8\u7269\u7ec6\u80de\u611f\u77e5\u6c27\u6c14\u53d8\u5316\u7684\u5206\u5b50\u5f00\u5173\u8fdb\u884c\u4e86\u5927\u91cf\u7814\u7a76\u3002 1991\u5e74\u4eba\u4eec\u53d1\u73b0\u4e00\u79cd\u7279\u5b9a\u7684DNA-\u86cb\u767d\u8d28\u590d\u5408\u7269\uff0c\u5176\u4f1a\u968f\u7740\u6c27\u6c14\u6d53\u5ea6\u7684\u53d8\u5316\u53d1\u751f\u76f8\u5e94\u7684\u6539\u53d8\uff0c\u8fd9\u4e2a\u86cb\u767d\u8d28\u88ab\u547d\u540d\u4e3a\u201c\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u201d\uff08Hif\uff09\u3002 2019\u5e74\uff0c\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u9881\u53d1\u7ed9\u4e86\u4e24\u4f4d\u7f8e\u56fd\u548c\u4e00\u4f4d\u82f1\u56fd\u79d1\u5b66\u5bb6\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u5728Hif\u7684\u53d1\u73b0\u53ca\u5176\u8c03\u8282\u4f4e\u6c27\u9002\u5e94\u7684\u529f\u80fd\u3002\u540c\u65f6\uff0c\u8fd9\u4e2a\u53d1\u73b0\u4e5f\u4e3a\u8d2b\u8840\u3001\u764c\u75c7\u548c\u8bb8\u591a\u5176\u4ed6\u75be\u75c5\u5f15\u8d77\u7684\u5c40\u90e8\u7f3a\u6c27\u7684\u7814\u7a76\u548c\u6cbb\u7597\u63d0\u4f9b\u6709\u7528\u7684\u7ebf\u7d22\u548c\u65b0\u7684\u6cbb\u7597\u601d\u8def\u3002 \u57fa\u4e8e\u524d\u671f\u7684\u7814\u7a76\u79ef\u7d2f\uff0c\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\uff0c\u53ea\u6709\u5f53\u751f\u7269\u4f53\u5904\u4e8e\u7f3a\u6c27\u73af\u5883\uff0c\u6216\u7ec4\u7ec7\u548c\u7ec6\u80de\u7b49\u5904\u4e8e\u7f3a\u6c27\u5fae\u73af\u5883\u65f6\uff0cHif\u901a\u8def\u624d\u80fd\u88ab\u6fc0\u6d3b\uff0c\u800c\u5728\u6b63\u5e38\u6c27\u542b\u91cf\u4e0bHif\u901a\u8def\u5904\u4e8e\u6291\u5236\u72b6\u6001\u3002 \u56db\u5e74\u524d\uff0c\u5eb7\u4e50\u56e2\u961f\u5e74\u8f7b\u4eba\u3001\u6b64\u6b21\u8bba\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u4e01\u738e\u5728\u897f\u85cf\u9ad8\u6d77\u62d4\u5730\u533a\uff0c\u7528\u5206\u5b50\u751f\u7269\u5b66\u624b\u6bb5\u7814\u7a76\u98de\u8757\u4f4e\u6c27\u9002\u5e94\u95ee\u9898\u7684\uff0c\u4e0e\u6240\u6709\u7814\u7a76\u4f4e\u6c27\u9002\u5e94\u95ee\u9898\u7684\u79d1\u5b66\u5bb6\u4e00\u6837\uff0cHif\u662f\u4ed6\u7814\u7a76\u4e2d\u7ed5\u4e0d\u5f00\u7684\u86cb\u767d\u8d28\u3002 \u98de\u8757\u662f\u4e00\u79cd\u6bcf\u5929\u53ef\u4ee5\u98de\u884c\u6570\u767e\u516c\u91cc\u7684\u519c\u4e1a\u5bb3\u866b\u3002\u957f\u9014\u98de\u884c\u65f6\uff0c\u98de\u8757\u6d88\u8017\u7684\u6c27\u6c14\u662f\u4f11\u606f\u65f6\u7684 30-150 \u500d\u3002\u5bf9\u4e8e\u5f88\u591a\u6606\u866b\u751f\u7269\u5b66\u7814\u7a76\u7684\u5b9e\u9a8c\u5ba4\u6765\u8bf4\uff0c\u679c\u8747\u662f\u6700\u57fa\u7840\u7684\u6a21\u5f0f\u6606\u866b\uff0c\u4f46\u8fd9\u4e2a\u5b9e\u9a8c\u56e2\u961f\u5374\u4e0d\u540c\uff0c\u4ed6\u4eec\u662f\u5168\u7403\u4ec5\u6709\u7684\u3001\u4ee5\u98de\u8757\u4f5c\u4e3a\u6a21\u5f0f\u6606\u866b\u7684\u5b9e\u9a8c\u56e2\u961f\u3002 \u4ed6\u4eec\u5148\u8ba9\u98de\u8757\u98de\u884c\u4e00\u6bb5\u65f6\u95f4\uff0c\u7136\u540e\u53d6\u4e0b\u98de\u8757\u7684\u98de\u884c\u808c\u8089\u7ec4\u7ec7\u505a\u86cb\u767d\u8d28\u5206\u6790\u3002\u5728\u98de\u8757\u7684\u98de\u884c\u808c\u4e2d\uff0c\u4ed6\u4eec\u51fa\u73b0\u4e86\u4e24\u79cd\u4e0d\u540c\u7684Hif\u86cb\u767d\u3002\u4e8e\u662f\uff0c\u4ed6\u4eec\u53c8\u5728\u7ec6\u80de\u5c42\u9762\u5206\u522b\u7814\u7a76\u8fd9\u4e24\u79cd\u86cb\u767d\u7684\u6d3b\u6027\u3002\u5f88\u5feb\uff0c\u4e00\u4e2a\u5947\u5f02\u7684\u73b0\u8c61\u5f15\u53d1\u4e86\u4e01\u738e\u7684\u6ce8\u610f\uff1a\u4e00\u79cdHif\u86cb\u767d\u53ea\u5728\u7f3a\u6c27\u65f6\u4e2d\u51fa\u73b0\uff0c\u800c\u53e6\u4e00\u79cdHif\u86cb\u767d\u5374\u53ef\u4ee5\u5728\u6709\u6c27\u73af\u5883\u4e0b\u7a33\u5b9a\u5b58\u5728\u3002\u800c\u4e14\uff0c\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0c\u98de\u8757\u5728\u5e38\u6c27\u60c5\u51b5\u4e0b\u98de\u884c\u65f6\uff0c\u98de\u884c\u808c\u4e2d\u8fd9\u79cd\u65b0\u7684\u86cb\u767d\u4f1a\u6025\u5267\u4e0a\u5347\u3002 \u201cHif\u901a\u8def\u4e0d\u662f\u53ea\u6709\u5728\u4f4e\u6c27\u73af\u5883\u4e0b\u624d\u4f1a\u88ab\u6fc0\u6d3b\u5417\uff1f\u201d\u4e01\u738e\u6709\u4e9b\u56f0\u60d1\u3002&#8230;<\/p>\n","protected":false},"author":1,"featured_media":614,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[18,538,537,466,536],"class_list":["post-613","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tech","tag-18","tag-538","tag-537","tag-466","tag-536"],"featured_image_urls":{"full":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a.jpg",530,767,false],"thumbnail":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a-150x150.jpg",150,150,true],"medium":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a-207x300.jpg",207,300,true],"medium_large":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a.jpg",530,767,false],"large":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a.jpg",530,767,false],"1536x1536":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a.jpg",530,767,false],"2048x2048":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a.jpg",530,767,false],"covernews-slider-full":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a-530x715.jpg",530,715,true],"covernews-slider-center":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a-530x500.jpg",530,500,true],"covernews-featured":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a.jpg",530,767,false],"covernews-medium":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a-530x340.jpg",530,340,true],"covernews-medium-square":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d70271415a-400x250.jpg",400,250,true]},"author_info":{"display_name":"admin","author_link":"https:\/\/demo3.aiwalls.com\/cn-news\/?author=1"},"category_info":"<a href=\"https:\/\/demo3.aiwalls.com\/cn-news\/?cat=8\" rel=\"category\">\u79d1\u6280\u8d44\u8baf<\/a>","tag_info":"\u79d1\u6280\u8d44\u8baf","comment_count":"0","_links":{"self":[{"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/posts\/613"}],"collection":[{"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=613"}],"version-history":[{"count":0,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/posts\/613\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/media\/614"}],"wp:attachment":[{"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}