{"id":607,"date":"2022-09-11T13:19:22","date_gmt":"2022-09-11T05:19:22","guid":{"rendered":"http:\/\/demo3.aiwalls.com\/cn-news\/index.php\/2022\/09\/11\/%e4%bb%8e%e5%9e%83%e5%9c%be%e6%a1%b6%e9%87%8c%e6%8d%a1%e5%9b%9e%e6%9d%a5%e7%9a%84%e7%a5%9e%e5%a5%87%e5%88%86%e5%ad%90%ef%bc%8c%e5%ae%83%e8%83%bd%e8%ae%a9%e8%a1%b0%e8%80%81%e7%9a%84\/"},"modified":"2022-09-11T13:19:22","modified_gmt":"2022-09-11T05:19:22","slug":"%e4%bb%8e%e5%9e%83%e5%9c%be%e6%a1%b6%e9%87%8c%e6%8d%a1%e5%9b%9e%e6%9d%a5%e7%9a%84%e7%a5%9e%e5%a5%87%e5%88%86%e5%ad%90%ef%bc%8c%e5%ae%83%e8%83%bd%e8%ae%a9%e8%a1%b0%e8%80%81%e7%9a%84","status":"publish","type":"post","link":"https:\/\/demo3.aiwalls.com\/cn-news\/?p=607","title":{"rendered":"\u4ece\u201c\u5783\u573e\u6876\u201d\u91cc\u6361\u56de\u6765\u7684\u795e\u5947\u5206\u5b50\uff0c\u5b83\u80fd\u8ba9\u8870\u8001\u7684\u5927\u8111\u7115\u53d1\u9752\u6625\u5417\uff1f"},"content":{"rendered":"<p id=\"157PAVVV\">\u258e\u836f\u660e\u5eb7\u5fb7\u5185\u5bb9\u56e2\u961f\u7f16\u8f91<\/p>\n<p id=\"157PB000\">\u5f53\u5361\u6885\u62c9\u00b7\u897f\u5fb7\u62c9\u65af\u57fa\uff08Carmela Sidrauski\uff09\u535a\u58eb\u6765\u5230\u62c9\u65af\u514b\u5956\u5f97\u4e3b\uff0c\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\uff08UCSF\uff09\u5f7c\u5f97\u00b7\u6c83\u5c14\u7279\uff08Peter Walter\uff09\u6559\u6388\u7684\u5b9e\u9a8c\u5ba4\u65f6\uff0c\u5979\u5e76\u6ca1\u6709\u60f3\u7740\u5bfb\u627e\u4e00\u79cd\u201c\u795e\u836f\u201d\u3002\u5728\u8fdb\u884c\u81ea\u52a8\u5316\u7b5b\u9009\u5b9e\u9a8c\u7684\u65f6\u5019\uff0c\u4e00\u6b3e\u88ab\u6392\u9664\u7684\u5316\u5408\u7269\u5438\u5f15\u4e86\u5979\u7684\u5174\u8da3\u3002\u5979\u628a\u5b83\u79fb\u5230\u503c\u5f97\u7ee7\u7eed\u7814\u7a76\u7684\u836f\u7269\u4e2d\uff0c\u56e0\u4e3a\u5b83\u7684\u6d3b\u6027\u8ba9\u4eba\u201c\u773c\u524d\u4e00\u4eae\u201d\u3002<\/p>\n<p id=\"157PB001\">\u5982\u4eca\u8fd9\u6b3e\u5206\u5b50\u7684\u6f5c\u5728\u7528\u9014\u542c\u8d77\u6765\u8ba9\u4eba\u96be\u4ee5\u7f6e\u4fe1\uff0c\u81ea\u4ece\u5361\u6885\u62c9\u51b3\u5b9a\u7ee7\u7eed\u7814\u7a76\u5b83\u4e4b\u540e\uff0c\u79d1\u5b66\u5b9e\u9a8c\u53d1\u73b0<strong>\u5b83\u4e0d\u4f46\u53ef\u4ee5\u6062\u590d\u5927\u8111\u635f\u4f24\u5c0f\u9f20\u7684\u8bb0\u5fc6\uff0c\u8fd8\u5728\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u5e15\u91d1\u68ee\u75c5\u3001\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\uff08ALS\uff0c\u53c8\u540d\u6e10\u51bb\u75c7\uff09\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u65b9\u9762\u663e\u793a\u51fa\u6f5c\u529b\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u80fd\u51cf\u5c11\u8870\u8001\u76f8\u5173\u7684\u8ba4\u77e5\u4e0b\u964d\uff0c\u5728\u5065\u5eb7\u5c0f\u9f20\u4e2d\uff0c\u8d4b\u4e88\u4e86\u5b83\u4eec\u201c\u8fc7\u76ee\u4e0d\u5fd8\u201d\u7684\u80fd\u529b\u3002<\/strong>\u662f\u4ec0\u4e48\u539f\u56e0\u8ba9\u5b83\u5177\u6709\u8fd9\u6837\u5e7f\u6cdb\u7684\u5e94\u7528\u5462\uff1f<\/p>\n<p class=\"f_center\"><img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/bm4iadvm3v32892.jpg\" \/><\/p>\n<p id=\"157PB003\">\u56fe\u7247\u6765\u6e90\uff1a123RF<\/p>\n<p id=\"157PB004\"><strong>\u4ece\u201c\u5783\u573e\u6876\u201d\u91cc\u6361\u56de\u6765\u7684\u795e\u5947\u5206\u5b50<\/strong><\/p>\n<p id=\"157PB005\">\u5728\u6c83\u5c14\u7279\u6559\u6388\u770b\u6765\uff0c\u8fd9\u53ef\u80fd\u662f\u56e0\u4e3a\u5b83\u6d89\u53ca\u5230\u7ef4\u6301\u7ec6\u80de\u5065\u5eb7\u7684\u4e00\u4e2a\u57fa\u672c\u673a\u5236\u3002\u8fd9\u4e2a\u673a\u5236\u79f0\u4e3a\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\uff08unfolded protein response\uff09\u3002\u7b80\u5355\u6765\u8bf4\uff0c<strong>\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u662f\u7ec6\u80de\u5728\u5236\u9020\u86cb\u767d\u8fc7\u7a0b\u4e2d\u7684\u8d28\u91cf\u63a7\u5236\u7cfb\u7edf<\/strong>\uff0c\u5f53\u5b83\u53d1\u73b0\u7ec6\u80de\u4e2d\u5b58\u5728\u8fc7\u591a\u7684\u672a\u6298\u53e0\u86cb\u767d\u65f6\uff0c\u4f1a\u6fc0\u6d3b\u4e24\u79cd\u4fe1\u53f7\u901a\u8def\uff0c\u4e00\u79cd\u4fe1\u53f7\u901a\u8def\u4f1a\u964d\u4f4e\u57fa\u56e0\u8868\u8fbe\uff0c\u51cf\u5c11\u86cb\u767d\u7684\u751f\u6210\uff0c\u53e6\u4e00\u4fe1\u53f7\u901a\u8def\u4f1a\u63d0\u9ad8\u86cb\u767d\u6298\u53e0\u7684\u80fd\u529b\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u534f\u52a9\u5e73\u8861\u5185\u8d28\u7f51\uff08ER\uff09\u6298\u53e0\u86cb\u767d\u7684\u80fd\u529b\u548c\u86cb\u767d\u751f\u4ea7\u7684\u6570\u91cf\uff0c\u8ba9\u7ec6\u80de\u4e2d\u6709\u8db3\u591f\u7684\u5185\u8d28\u7f51\u6765\u5b8c\u6210\u65b0\u751f\u86cb\u767d\u7684\u6298\u53e0\u3002<\/p>\n<p id=\"157PB006\">\u7136\u800c\uff0c\u5982\u679c\u56e0\u4e3a\u75be\u75c5\u6216\u8005\u5176\u5b83\u539f\u56e0\u5bfc\u81f4\u7ec6\u80de\u4e2d\u7684ER\u4e0d\u8db3\u4ee5\u5b8c\u6210\u86cb\u767d\u6298\u53e0\uff0c\u4f1a\u5bfc\u81f4\u5927\u91cf\u7684\u672a\u6298\u53e0\u86cb\u767d\u79ef\u7d2f\u5728ER\u4e2d\u3002<strong>\u5f53ER\u201c\u4e0d\u582a\u91cd\u8d1f\u201d\u7684\u65f6\u5019\uff0c\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u4f1a\u5bfc\u81f4\u7ec6\u80de\u7684\u6b7b\u4ea1\uff0c<\/strong><strong>\u8fd9\u4e0e\u591a\u79cd\u75be\u75c5\u76f8\u5173\u3002<\/strong>\u6bd4\u5982\u57282\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\uff0c\u5bf9\u80f0\u5c9b\u7d20\u7684\u4e0d\u65ad\u9700\u6c42\u53ef\u80fd\u5bfc\u81f4\u80f0\u5c9b\u03b2\u7ec6\u80de\u56e0\u4e3a\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u800c\u6b7b\u4ea1\u3002\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\uff0c\u968f\u7740\u86cb\u767d\u805a\u96c6\u7269\u7684\u79ef\u7d2f\uff0c\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u4e5f\u53ef\u4ee5\u6740\u6b7b\u795e\u7ecf\u7ec6\u80de\u3002<\/p>\n<p class=\"f_center\"><img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/y3jqnzpx0442893.jpg\" \/><\/p>\n<p id=\"157PB008\">\u622a\u56fe\u6765\u6e90\uff1a\u62c9\u65af\u514b\u57fa\u91d1\u4f1a\u5b98\u7f51<\/p>\n<p id=\"157PB009\">\u6c83\u5c14\u7279\u6559\u6388\u56e0\u4e3a\u5bf9\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u7684\u7814\u7a76\u57282014\u5e74\u83b7\u5f97\u4e86\u62c9\u65af\u514b\u57fa\u7840\u533b\u5b66\u7814\u7a76\u5956\uff0c\u5e76\u4e14\u57282018\u5e74\u83b7\u5f97\u4e86\u88ab\u8a89\u4e3a\u201c\u79d1\u5b66\u754c\u7684\u5965\u65af\u5361\u201d\u7684\u79d1\u5b66\u7a81\u7834\u5956\uff08Breakthrough Prize\uff09\u3002\u5728\u4ed6\u770b\u6765\uff0c<strong>\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u662f\u5e2e\u52a9\u5927\u8111\u4fee\u590d\u53d7\u635f\u8bb0\u5fc6\u901a\u8def\u201c\u5c1a\u672a\u88ab\u53d1\u6398\u7684\u91d1\u77ff\u201d\uff0c\u5982\u679c\u80fd\u591f\u63a7\u5236\u8fd9\u4e00\u53cd\u5e94\uff0c\u5c31\u6709\u53ef\u80fd\u4fee\u597d\u75be\u75c5\u7ec6\u80de\u4e2d\u51fa\u73b0\u969c\u788d\u7684\u7ec6\u80de\u673a\u5236\uff0c\u5982\u679c\u80fd\u591f\u4fee\u597d\u60a3\u75c5\u7684\u7ec6\u80de\uff0c\u5c31\u80fd\u591f\u6cbb\u6108\u60a3\u8005\u3002<\/strong><\/p>\n<p id=\"157PB00A\">\u4f46\u662f\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u7684\u8c03\u63a7\u9519\u7efc\u590d\u6742\uff0c\u54ea\u91cc\u662f\u80fd\u591f\u8c03\u63a7\u53cd\u5e94\u7684\u5173\u952e\u8282\u70b9\uff1f\u4e3a\u6b64\uff0c\u6c83\u5c14\u7279\u6559\u6388\u4e0eUCSF\u7684\u5c0f\u5206\u5b50\u53d1\u73b0\u4e2d\u5fc3\u5408\u4f5c\uff0c\u5229\u7528\u9ad8\u901a\u91cf\u7b5b\u9009\uff0c\u68c0\u6d4b\u8d85\u8fc710\u4e07\u79cd\u5316\u5408\u7269\u5bf9\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u7684\u5f71\u54cd\u3002\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\u5361\u6885\u62c9\u8d1f\u8d23\u8fd9\u4e2a\u9879\u76ee\u3002<\/p>\n<p id=\"157PB00B\">\u4e00\u5929\uff0c\u5361\u6885\u62c9\u5728\u68c0\u67e5\u81ea\u52a8\u5316\u7b5b\u9009\u6dd8\u6c70\u7684\u836f\u7269\u6570\u636e\u7684\u65f6\u5019\uff0c\u4e00\u6b3e\u5206\u5b50\u5438\u5f15\u4e86\u5979\u7684\u6ce8\u610f\u529b\u3002\u8fd9\u6b3e\u5206\u5b50\u7684\u6548\u529b\u8fdc\u8fdc\u5f3a\u4e8e\u5176\u5b83\u7684\u5206\u5b50\uff0c\u5b83\u4e4b\u6240\u4ee5\u88ab\u6dd8\u6c70\uff0c\u662f\u56e0\u4e3a\u540e\u7eed\u68c0\u6d4b\u663e\u793a\u5b83\u53ef\u80fd\u53ef\u6eb6\u6027\u4e0d\u4f73\uff0c\u65e0\u6cd5\u6210\u4e3a\u6f5c\u5728\u836f\u7269\u3002<\/p>\n<p id=\"157PB00C\">\u201c\u8fd9\u4e0d\u662f\u4e22\u6389\u5b83\u7684\u539f\u56e0\u3002\u201d\u5979\u60f3\uff0c\u201c\u5b83\u7684\u6548\u529b\u975e\u5e38\u5f3a\uff01\u201d\u5979\u51b3\u5b9a\u8d4c\u4e0a\u4e00\u628a\uff0c\u8d2d\u4e70\u4e86\u66f4\u5927\u91cf\u7684\u8fd9\u79cd\u5316\u5408\u7269\u8fdb\u884c\u540e\u7eed\u7814\u7a76\u3002<\/p>\n<p id=\"157PB00D\">\u540e\u7eed\u7814\u7a76\u53d1\u73b0\uff0c<strong>\u8fd9\u4e2a\u5206\u5b50\u4e0d\u4f46\u53ef\u4ee5\u91cd\u542f\u5e94\u6fc0\u56e0\u5b50\u4e2d\u6b62\u7684\u7ec6\u80de\u86cb\u767d\u5408\u6210\uff0c\u66f4\u795e\u5947\u7684\u662f\uff0c\u8fd9\u4e2a\u6548\u679c\u51e0\u4e4e\u5bf9\u6240\u6709\u5e94\u6fc0\u56e0\u5b50\u90fd\u6709\u6548\u3002<\/strong><\/p>\n<p id=\"157PB00E\"><strong>\u589e\u5f3a\u8bb0\u5fc6<\/strong><\/p>\n<p id=\"157PB00F\">\u800c\u86cb\u767d\u5408\u6210\u5728\u957f\u671f\u8bb0\u5fc6\u7684\u5f62\u6210\u4e2d\u8d77\u5230\u91cd\u8981\u4f5c\u7528\u3002\u5f88\u4e45\u4ee5\u6765\uff0c\u79d1\u5b66\u7814\u7a76\u663e\u793a\uff0c\u5927\u8111\u7684\u8bb0\u5fc6\u5b58\u50a8\u5728\u4e0d\u540c\u795e\u7ecf\u7ec6\u80de\u6784\u6210\u7684\u7f51\u7edc\u4e2d\uff0c<strong>\u86cb\u767d\u5408\u6210\u5bf9\u8c03\u8282\u795e\u7ecf\u7ec6\u80de\u4e4b\u95f4\u4f20\u9012\u4fe1\u606f\u7684\u795e\u7ecf\u7a81\u89e6\u81f3\u5173\u91cd\u8981\u3002\u5982\u679c\u964d\u4f4e\u86cb\u767d\u5408\u6210\u6c34\u5e73\uff0c\u5c31\u4f1a\u5f71\u54cd\u957f\u671f\u8bb0\u5fc6\u7684\u5f62\u6210\u3002<\/strong><strong>\u800c\u5e94\u6fc0\u53cd\u5e94\u7684\u4e00\u4e2a\u540e\u679c\u5c31\u662f\u964d\u4f4e\u86cb\u767d\u5408\u6210\u7684\u6c34\u5e73\uff0c\u90a3\u4e48\u5982\u679c\u963b\u6b62\u5e94\u6fc0\u53cd\u5e94\u7684\u8fd9\u4e2a\u540e\u679c\uff0c\u80fd\u5426\u8d77\u5230\u589e\u5f3a\u8bb0\u5fc6\u7684\u4f5c\u7528\u5462\uff1f<\/strong><\/p>\n<p id=\"157PB00G\">\u6c83\u5c14\u7279\u6559\u6388\u5b9e\u9a8c\u5ba4\u4e0e\u9ea6\u5409\u5c14\u5927\u5b66\uff08McGill University\uff09\u7684\u5408\u4f5c\u4f19\u4f34\u4e00\u8d77\uff0c\u68c0\u6d4b\u4e86\u8fd9\u6b3e\u540d\u4e3aISRIB\u7684\u5316\u5408\u7269\u5728\u5c0f\u9f20\u4e2d\u7684\u6548\u679c\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u5f53\u628a\u8fd9\u79cd\u5316\u5408\u7269\u6ce8\u5c04\u5230\u5c0f\u9f20\u4f53\u5185\u540e\uff0c\u5b83\u80fd\u591f\u8fc5\u901f\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u5e76\u4e14\u6ca1\u6709\u8868\u73b0\u51fa\u6bd2\u6027\u3002\u800c\u4e14<strong>\u63a5\u53d7ISRIB\u6ce8\u5c04\u7684\u5c0f\u9f20\u80fd\u591f\u5728\u8ff7\u5bab\u6d4b\u8bd5\u4e2d\u8fc5\u901f\u8bb0\u4f4f\u9690\u85cf\u5728\u6c34\u9762\u4e0b\u5e73\u53f0\u7684\u4f4d\u7f6e\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u53d1\u73b0\u5e73\u53f0\u7684\u901f\u5ea6\u63d0\u9ad8\u4e863\u500d\u3002<\/strong>\u8fd9\u610f\u5473\u7740\u8fd9\u6b3e\u5316\u5408\u7269\u5177\u6709\u589e\u5f3a\u8bb0\u5fc6\u7684\u4f5c\u7528\u3002<\/p>\n<p id=\"157PB00H\">\u8fd9\u4e00\u7ed3\u679c\u53d1\u8868\u4e4b\u540e\u5f97\u5230\u4e86\u7845\u8c37\u6295\u8d44\u4eba\u7684\u5173\u6ce8\u3002<strong>2015\u5e74\uff0c\u7531\u8c37\u6b4c\u6bcd\u516c\u53f8Alphabet\u521b\u5efa\u7684\u751f\u547d\u79d1\u5b66\u516c\u53f8Calico\u5ba3\u5e03\u83b7\u5f97\u8fd9\u4e00\u5316\u5408\u7269\u7684\u5f00\u53d1\u6743\u76ca<\/strong>\u3002\u8fd9\u662f\u4e00\u5bb6\u7531\u57fa\u56e0\u6cf0\u514b\u524d\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98Arthur D. Levinson\u535a\u58eb\u9886\u5bfc\uff0c\u5229\u7528\u5148\u8fdb\u6280\u672f\u6765\u589e\u8fdb\u5bf9\u8870\u8001\u548c\u5bff\u547d\u7684\u751f\u7269\u5b66\u7406\u89e3\u7684\u516c\u53f8\u3002\u5361\u6885\u62c9\u4e5f\u52a0\u76dfCalico\u516c\u53f8\uff0c\u62c5\u4efb\u8be5\u516c\u53f8\u7684\u4e34\u65f6\u7814\u53d1\u8d1f\u8d23\u4eba\uff0c\u7ee7\u7eed\u5f15\u9886\u8fd9\u4e00\u9879\u76ee\u7684\u5f00\u53d1\u3002<\/p>\n<p class=\"f_center\"><img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/vqwoplrsbnb2894.jpg\" \/><\/p>\n<p id=\"157PB00J\">\u56fe\u7247\u6765\u6e90\uff1aCalico\u516c\u53f8\u5b98\u7f51<\/p>\n<p id=\"157PB00K\">\u76ee\u524d\uff0c<strong>\u57fa\u4e8eISRIB\u5f00\u53d1\u7684\u5728\u7814\u7597\u6cd5ABBV-CLS-7262\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c\u7528\u4e8e\u6cbb\u7597\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316<\/strong>\u3002Calico\u5df2\u7ecf\u4e0e\u827e\u4f2f\u7ef4\uff08AbbVie\uff09\u8fbe\u6210\u5408\u4f5c\uff0c\u8054\u5408\u8fdb\u884c\u8fd9\u4e00\u7597\u6cd5\u7684\u5f00\u53d1\u3002<\/p>\n<p id=\"157PB00L\"><strong>\u8ba9\u8870\u8001\u7684\u5927\u8111\u7115\u53d1\u9752\u6625<\/strong><\/p>\n<p id=\"157PB00M\">\u6c83\u5c14\u7279\u6559\u6388\u7684\u56e2\u961f\u4e0e\u5408\u4f5c\u4f19\u4f34\u4e00\u8d77\uff0c\u968f\u540e\u5728\u8870\u8001\u5c0f\u9f20\u4e2d\u68c0\u9a8c\u4e86\u8fd9\u79cd\u5316\u5408\u7269\u7684\u6548\u679c\u3002\u968f\u7740\u4eba\u4eec\u5e74\u9f84\u7684\u589e\u957f\uff0c\u8ba4\u77e5\u6c34\u5e73\u7684\u8870\u9000\u662f\u975e\u5e38\u5e38\u89c1\u7684\u73b0\u8c61\u3002\u6211\u4eec\u90fd\u77e5\u9053\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4f1a\u663e\u8457\u964d\u4f4e\u8001\u4eba\u7684\u8ba4\u77e5\u6c34\u5e73\u3002\u7136\u800c\u5373\u4f7f\u5728\u5065\u5eb7\u7684\u8001\u5e74\u4eba\u4e2d\uff0c\u8ba4\u77e5\u548c\u8bb0\u5fc6\u80fd\u529b\uff0c\u4ee5\u53ca\u7528\u4e8e\u65e5\u5e38\u6d3b\u52a8\u7684\u6267\u884c\u80fd\u529b\u4e5f\u4f1a\u6709\u6240\u4e0b\u964d\u3002\u968f\u7740\u4e16\u754c\u4eba\u53e3\u7684\u8001\u9f84\u5316\uff0c\u5982\u4f55\u8ba9\u4eba\u4eec\u5728\u66f4\u4e3a\u957f\u5bff\u7684\u540c\u65f6\uff0c\u62e5\u6709\u66f4\u4e3a\u5065\u5eb7\u7684\u672a\u6765\u662f\u6025\u9700\u89e3\u51b3\u7684\u95ee\u9898\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\u5185\u5bb9\u56e2\u961f\u7f16\u8f91 \u5f53\u5361\u6885\u62c9\u00b7\u897f\u5fb7\u62c9\u65af\u57fa\uff08Carmela Sidrauski\uff09\u535a\u58eb\u6765\u5230\u62c9\u65af\u514b\u5956\u5f97\u4e3b\uff0c\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\uff08UCSF\uff09\u5f7c\u5f97\u00b7\u6c83\u5c14\u7279\uff08Peter Walter\uff09\u6559\u6388\u7684\u5b9e\u9a8c\u5ba4\u65f6\uff0c\u5979\u5e76\u6ca1\u6709\u60f3\u7740\u5bfb\u627e\u4e00\u79cd\u201c\u795e\u836f\u201d\u3002\u5728\u8fdb\u884c\u81ea\u52a8\u5316\u7b5b\u9009\u5b9e\u9a8c\u7684\u65f6\u5019\uff0c\u4e00\u6b3e\u88ab\u6392\u9664\u7684\u5316\u5408\u7269\u5438\u5f15\u4e86\u5979\u7684\u5174\u8da3\u3002\u5979\u628a\u5b83\u79fb\u5230\u503c\u5f97\u7ee7\u7eed\u7814\u7a76\u7684\u836f\u7269\u4e2d\uff0c\u56e0\u4e3a\u5b83\u7684\u6d3b\u6027\u8ba9\u4eba\u201c\u773c\u524d\u4e00\u4eae\u201d\u3002 \u5982\u4eca\u8fd9\u6b3e\u5206\u5b50\u7684\u6f5c\u5728\u7528\u9014\u542c\u8d77\u6765\u8ba9\u4eba\u96be\u4ee5\u7f6e\u4fe1\uff0c\u81ea\u4ece\u5361\u6885\u62c9\u51b3\u5b9a\u7ee7\u7eed\u7814\u7a76\u5b83\u4e4b\u540e\uff0c\u79d1\u5b66\u5b9e\u9a8c\u53d1\u73b0\u5b83\u4e0d\u4f46\u53ef\u4ee5\u6062\u590d\u5927\u8111\u635f\u4f24\u5c0f\u9f20\u7684\u8bb0\u5fc6\uff0c\u8fd8\u5728\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u5e15\u91d1\u68ee\u75c5\u3001\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\uff08ALS\uff0c\u53c8\u540d\u6e10\u51bb\u75c7\uff09\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u65b9\u9762\u663e\u793a\u51fa\u6f5c\u529b\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u80fd\u51cf\u5c11\u8870\u8001\u76f8\u5173\u7684\u8ba4\u77e5\u4e0b\u964d\uff0c\u5728\u5065\u5eb7\u5c0f\u9f20\u4e2d\uff0c\u8d4b\u4e88\u4e86\u5b83\u4eec\u201c\u8fc7\u76ee\u4e0d\u5fd8\u201d\u7684\u80fd\u529b\u3002\u662f\u4ec0\u4e48\u539f\u56e0\u8ba9\u5b83\u5177\u6709\u8fd9\u6837\u5e7f\u6cdb\u7684\u5e94\u7528\u5462\uff1f \u56fe\u7247\u6765\u6e90\uff1a123RF \u4ece\u201c\u5783\u573e\u6876\u201d\u91cc\u6361\u56de\u6765\u7684\u795e\u5947\u5206\u5b50 \u5728\u6c83\u5c14\u7279\u6559\u6388\u770b\u6765\uff0c\u8fd9\u53ef\u80fd\u662f\u56e0\u4e3a\u5b83\u6d89\u53ca\u5230\u7ef4\u6301\u7ec6\u80de\u5065\u5eb7\u7684\u4e00\u4e2a\u57fa\u672c\u673a\u5236\u3002\u8fd9\u4e2a\u673a\u5236\u79f0\u4e3a\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\uff08unfolded protein response\uff09\u3002\u7b80\u5355\u6765\u8bf4\uff0c\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u662f\u7ec6\u80de\u5728\u5236\u9020\u86cb\u767d\u8fc7\u7a0b\u4e2d\u7684\u8d28\u91cf\u63a7\u5236\u7cfb\u7edf\uff0c\u5f53\u5b83\u53d1\u73b0\u7ec6\u80de\u4e2d\u5b58\u5728\u8fc7\u591a\u7684\u672a\u6298\u53e0\u86cb\u767d\u65f6\uff0c\u4f1a\u6fc0\u6d3b\u4e24\u79cd\u4fe1\u53f7\u901a\u8def\uff0c\u4e00\u79cd\u4fe1\u53f7\u901a\u8def\u4f1a\u964d\u4f4e\u57fa\u56e0\u8868\u8fbe\uff0c\u51cf\u5c11\u86cb\u767d\u7684\u751f\u6210\uff0c\u53e6\u4e00\u4fe1\u53f7\u901a\u8def\u4f1a\u63d0\u9ad8\u86cb\u767d\u6298\u53e0\u7684\u80fd\u529b\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u534f\u52a9\u5e73\u8861\u5185\u8d28\u7f51\uff08ER\uff09\u6298\u53e0\u86cb\u767d\u7684\u80fd\u529b\u548c\u86cb\u767d\u751f\u4ea7\u7684\u6570\u91cf\uff0c\u8ba9\u7ec6\u80de\u4e2d\u6709\u8db3\u591f\u7684\u5185\u8d28\u7f51\u6765\u5b8c\u6210\u65b0\u751f\u86cb\u767d\u7684\u6298\u53e0\u3002 \u7136\u800c\uff0c\u5982\u679c\u56e0\u4e3a\u75be\u75c5\u6216\u8005\u5176\u5b83\u539f\u56e0\u5bfc\u81f4\u7ec6\u80de\u4e2d\u7684ER\u4e0d\u8db3\u4ee5\u5b8c\u6210\u86cb\u767d\u6298\u53e0\uff0c\u4f1a\u5bfc\u81f4\u5927\u91cf\u7684\u672a\u6298\u53e0\u86cb\u767d\u79ef\u7d2f\u5728ER\u4e2d\u3002\u5f53ER\u201c\u4e0d\u582a\u91cd\u8d1f\u201d\u7684\u65f6\u5019\uff0c\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u4f1a\u5bfc\u81f4\u7ec6\u80de\u7684\u6b7b\u4ea1\uff0c\u8fd9\u4e0e\u591a\u79cd\u75be\u75c5\u76f8\u5173\u3002\u6bd4\u5982\u57282\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\uff0c\u5bf9\u80f0\u5c9b\u7d20\u7684\u4e0d\u65ad\u9700\u6c42\u53ef\u80fd\u5bfc\u81f4\u80f0\u5c9b\u03b2\u7ec6\u80de\u56e0\u4e3a\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u800c\u6b7b\u4ea1\u3002\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\uff0c\u968f\u7740\u86cb\u767d\u805a\u96c6\u7269\u7684\u79ef\u7d2f\uff0c\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u4e5f\u53ef\u4ee5\u6740\u6b7b\u795e\u7ecf\u7ec6\u80de\u3002 \u622a\u56fe\u6765\u6e90\uff1a\u62c9\u65af\u514b\u57fa\u91d1\u4f1a\u5b98\u7f51 \u6c83\u5c14\u7279\u6559\u6388\u56e0\u4e3a\u5bf9\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u7684\u7814\u7a76\u57282014\u5e74\u83b7\u5f97\u4e86\u62c9\u65af\u514b\u57fa\u7840\u533b\u5b66\u7814\u7a76\u5956\uff0c\u5e76\u4e14\u57282018\u5e74\u83b7\u5f97\u4e86\u88ab\u8a89\u4e3a\u201c\u79d1\u5b66\u754c\u7684\u5965\u65af\u5361\u201d\u7684\u79d1\u5b66\u7a81\u7834\u5956\uff08Breakthrough Prize\uff09\u3002\u5728\u4ed6\u770b\u6765\uff0c\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u662f\u5e2e\u52a9\u5927\u8111\u4fee\u590d\u53d7\u635f\u8bb0\u5fc6\u901a\u8def\u201c\u5c1a\u672a\u88ab\u53d1\u6398\u7684\u91d1\u77ff\u201d\uff0c\u5982\u679c\u80fd\u591f\u63a7\u5236\u8fd9\u4e00\u53cd\u5e94\uff0c\u5c31\u6709\u53ef\u80fd\u4fee\u597d\u75be\u75c5\u7ec6\u80de\u4e2d\u51fa\u73b0\u969c\u788d\u7684\u7ec6\u80de\u673a\u5236\uff0c\u5982\u679c\u80fd\u591f\u4fee\u597d\u60a3\u75c5\u7684\u7ec6\u80de\uff0c\u5c31\u80fd\u591f\u6cbb\u6108\u60a3\u8005\u3002 \u4f46\u662f\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u7684\u8c03\u63a7\u9519\u7efc\u590d\u6742\uff0c\u54ea\u91cc\u662f\u80fd\u591f\u8c03\u63a7\u53cd\u5e94\u7684\u5173\u952e\u8282\u70b9\uff1f\u4e3a\u6b64\uff0c\u6c83\u5c14\u7279\u6559\u6388\u4e0eUCSF\u7684\u5c0f\u5206\u5b50\u53d1\u73b0\u4e2d\u5fc3\u5408\u4f5c\uff0c\u5229\u7528\u9ad8\u901a\u91cf\u7b5b\u9009\uff0c\u68c0\u6d4b\u8d85\u8fc710\u4e07\u79cd\u5316\u5408\u7269\u5bf9\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\u7684\u5f71\u54cd\u3002\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u540e\u5361\u6885\u62c9\u8d1f\u8d23\u8fd9\u4e2a\u9879\u76ee\u3002&#8230;<\/p>\n","protected":false},"author":1,"featured_media":608,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[526,527,18,525,528],"class_list":["post-607","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tech","tag-526","tag-527","tag-18","tag-525","tag-528"],"featured_image_urls":{"full":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f.jpg",640,360,false],"thumbnail":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f-150x150.jpg",150,150,true],"medium":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f-300x169.jpg",300,169,true],"medium_large":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f.jpg",640,360,false],"large":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f.jpg",640,360,false],"1536x1536":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f.jpg",640,360,false],"2048x2048":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f.jpg",640,360,false],"covernews-slider-full":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f.jpg",640,360,false],"covernews-slider-center":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f.jpg",640,360,false],"covernews-featured":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f.jpg",640,360,false],"covernews-medium":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f-540x340.jpg",540,340,true],"covernews-medium-square":["https:\/\/demo3.aiwalls.com\/cn-news\/wp-content\/uploads\/1662\/73631d6fda7277f-400x250.jpg",400,250,true]},"author_info":{"display_name":"admin","author_link":"https:\/\/demo3.aiwalls.com\/cn-news\/?author=1"},"category_info":"<a href=\"https:\/\/demo3.aiwalls.com\/cn-news\/?cat=8\" rel=\"category\">\u79d1\u6280\u8d44\u8baf<\/a>","tag_info":"\u79d1\u6280\u8d44\u8baf","comment_count":"0","_links":{"self":[{"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/posts\/607"}],"collection":[{"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=607"}],"version-history":[{"count":0,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/posts\/607\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=\/wp\/v2\/media\/608"}],"wp:attachment":[{"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=607"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/demo3.aiwalls.com\/cn-news\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}