{"id":605,"date":"2022-09-11T13:18:33","date_gmt":"2022-09-11T05:18:33","guid":{"rendered":"http:\/\/demo3.aiwalls.com\/cn-news\/index.php\/2022\/09\/11\/%e4%bb%8e%e5%ba%94%e6%bf%80%e5%88%b0%e6%85%a2%e6%80%a7%e7%82%8e%e7%97%87%ef%bc%8c%e5%86%8d%e5%88%b0%e8%82%bf%e7%98%a4\/"},"modified":"2022-09-11T13:18:33","modified_gmt":"2022-09-11T05:18:33","slug":"%e4%bb%8e%e5%ba%94%e6%bf%80%e5%88%b0%e6%85%a2%e6%80%a7%e7%82%8e%e7%97%87%ef%bc%8c%e5%86%8d%e5%88%b0%e8%82%bf%e7%98%a4","status":"publish","type":"post","link":"https:\/\/demo3.aiwalls.com\/cn-news\/?p=605","title":{"rendered":"\u4ece\u201c\u5e94\u6fc0\u201d\u5230\u201c\u6162\u6027\u708e\u75c7\u201d\uff0c\u518d\u5230\u201c\u80bf\u7624\u201d"},"content":{"rendered":"<p id=\"157O7EEB\">\u65e5\u5e38\u201c\u5e94\u6fc0\u201d\u6d47\u7684\u6c34\uff0c\u6ecb\u517b\u4e86\u4eba\u4f53\u201c\u6162\u6027\u708e\u75c7\u201d\u7684\u201c\u571f\u58e4\u201d\uff0c\u662f\u4e00\u7cfb\u5217\u75be\u75c5\uff08\u80bf\u7624\u3001\u5fc3\u8840\u7ba1\u3001\u4ee3\u8c22\u75c5\u7b49\uff09\u7684\u57fa\u7840\u3002<\/p>\n<p id=\"157O7EEC\">1936\u5e74\uff0c\u52a0\u62ff\u5927\u75c5\u7406\u751f\u7406\u5b66\u5bb6<strong>Hans Sely<\/strong>\u9996\u5148\u63d0\u51fa\u4e86\u5e94\u6fc0\u7684\u6982\u5ff5[1]\u3002<strong>\u5e94\u6fc0<\/strong><strong>\uff08Stress\uff09\uff0c<\/strong><strong>\u4f7f\u673a\u4f53\u80fd\u591f\u5e94\u5bf9\u6311\u6218\u5e76\u6062\u590d\u5185\u7a33\u6001\uff0c<\/strong><strong>\u662f\u673a\u4f53\u4e00\u79cd\u5fc5\u4e0d\u53ef\u5c11\u7684\u9002\u5e94\u6027\u53cd\u5e94\uff0c\u53c8\u79f0\u4e3a\u201c\u5e94\u6fc0\u53cd\u5e94\u201d<\/strong>\u3002\u4e0d\u540c\u7684\u5e94\u6fc0\u6e90\u62e5\u6709\u72ec\u7279\u7684\u7ea0\u6b63\u53cd\u5e94\uff0c\u5176\u4e2d\u514d\u75ab\u7ec6\u80de\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<p id=\"157O7EED\"><strong>&#8211;<\/strong><strong>01 &#8211;<\/strong><\/p>\n<p id=\"157O7EEE\"><strong>\u5e94\u6fc0\u7684\u53d1\u751f<\/strong><\/p>\n<p id=\"157O7EEF\">\u5e94\u6fc0\uff08Stress\uff09\uff0c<strong>\u673a\u4f53\u5bf9\u4e8e\u4efb\u4f55\u9020\u6210\u751f\u7406\u6216\u5fc3\u7406\u6539\u53d8\u7684\u523a\u6fc0\u505a\u51fa\u7684\u4e00\u4e9b\u53cd\u5e94<\/strong>\u3002<\/p>\n<p id=\"157O7EEG\">\u673a\u4f53\u611f\u53d7\u5230\u751f\u7406\u548c\/\u6216\u5fc3\u7406\u5e94\u6fc0\uff0c\u901a\u8fc7\u4e0b\u4e18\u8111-\u5782\u4f53-\u80be\u4e0a\u817a\uff08HPA\uff09\u8f74\u548c\u4ea4\u611f\u795e\u7ecf-\u80be\u4e0a\u817a-\u9ad3\u8d28\uff08SAM\uff09\u8f74\uff0c\u91ca\u653e\u4ecb\u8d28\uff0c\u4ecb\u8d28\u901a\u8fc7\u7ed3\u5408\u76f8\u5e94\u53d7\u4f53\uff0c\u4f7f\u673a\u4f53\u53d1\u751f\u76f8\u5e94\u6539\u53d8\uff08\u80fd\u529b\u4ee3\u8c22\u52a8\u5458\u3001\u514d\u75ab\u7cfb\u6d3b\u5316\u7b49\uff09\uff0c\u4ee5\u9002\u5e94\u53d1\u751f\u7684\u5e94\u6fc0\u523a\u6fc0\u3002<\/p>\n<p class=\"f_center\"><img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/tpzxgfbpzkb2896.jpg\" \/><\/p>\n<p id=\"157O7EEH\">Front. Behav. Neurosci. 12, 127<\/p>\n<p id=\"157O7EEI\">\u5e94\u6fc0\uff0c\u662f\u4e00\u4e2a\u5e7f\u6cdb\u7684\u3001\u5305\u7f57\u4e07\u8c61\u7684\u672f\u8bed\uff0c\u5305\u62ec\u4efb\u4f55\u7a33\u6001\u504f\u79bb\u3002<\/p>\n<p id=\"157O7EEJ\"><strong>&#8211;<\/strong><strong>02 &#8211;<\/strong><\/p>\n<p id=\"157O7EEK\"><strong>\u5e94\u6fc0\u4e0e\u514d\u75ab\u7684\u5173\u7cfb<\/strong><\/p>\n<p id=\"157O7EEL\">\u5e94\u6fc0\u5bf9\u514d\u75ab\u7684\u5f71\u54cd\uff0c\u53ef\u4ee5\u662f<strong>\u8bf1\u5bfc\u708e\u75c7\u514d\u75ab\u53cd\u5e94<\/strong>\uff0c\u4e5f\u53ef\u4ee5\u662f<strong>\u514d\u75ab\u6291\u5236<\/strong>\u3002<\/p>\n<p id=\"157O7EEM\">\u4ece\u6d41\u884c\u75c5\u5b66\u89d2\u5ea6\u770b\uff0c\u5e94\u6fc0\u4e0e\u6162\u6027\u708e\u75c7\u76f8\u5173\u75be\u75c5\u7684\u51fa\u73b0\u548c\u52a0\u91cd\u76f8\u5173\uff0c\u5305\u62ec\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08SLE\uff09\u3001\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08MS\uff09\u3001\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff08RA\uff09\u548c\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\u7b49\u3002<\/p>\n<p id=\"157O7EEN\">\u5e94\u6fc0\u8bf1\u5bfc\u7684\u4ecb\u8d28\uff08\u5982\u795e\u7ecf\u9012\u8d28\u3001\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u6216\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7b49\u5e38\u89c1\u7684\u5e94\u6fc0\u6fc0\u7d20\uff09\uff0c\u4f1a\u4ea7\u751f\u514d\u75ab\u6291\u5236\u3002<\/p>\n<p class=\"f_center\"><img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/5vhvxga2gqa2897.jpg\" \/><\/p>\n<p id=\"157O7EEO\">Immunity 54, September 14, 2021<\/p>\n<p id=\"157O7EEP\">\u5185\u5206\u6ccc\u548c\u795e\u7ecf\u5143\u4fe1\u53f7\uff0c\u53ef<strong>\u76f4\u63a5\u4f5c\u7528<\/strong>\u514d\u75ab\u7ec6\u80de\uff0c\u4e5f\u53ef<strong>\u95f4\u63a5\u4f5c\u7528<\/strong>\u5468\u56f4\u7ec4\u7ec7\u6765\u5f71\u54cd\u514d\u75ab\u7cfb\u7edf\u7684\u529f\u80fd\u3002<\/p>\n<p id=\"157O7EEQ\"><strong>\u2589<\/strong><strong>\u76f4\u63a5\u4f5c\u7528<\/strong><\/p>\n<p id=\"157O7EER\">\u81ea\u4e3b\u795e\u7ecf\u7cfb\u7edf\u652f\u914d\u80be\u4e0a\u817a\u9ad3\u8d28\uff0c\u8bf1\u5bfc\u5176\u5206\u6ccc\u513f\u8336\u915a\u80fa\u8fdb\u5165\u8840\u6db2\u3002\u5728\u6dcb\u5df4\u7ed3\u548c\u813e\u810f\u5185\uff0c\u5404\u79cd\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u4ecd\u7136\u4e0e\u4ea4\u611f\u795e\u7ecf\u7ea4\u7ef4\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n<p id=\"157O7EES\">\u514d\u75ab\u7ec6\u80de\uff0c\u4ece\u8fd9\u4e9b\u9694\u95f4\u4e2d\u7684\u795e\u7ecf\u7ea4\u7ef4\u4e2d\u63a5\u6536\u5230\u7684\u4fe1\u53f7\uff0c\u53ef\u80fd\u4f1a\u5f71\u54cd\u514d\u75ab\u7ec6\u80de\u57fa\u56e0\u7684\u8868\u8fbe\u3001\u6210\u719f\u3001\u8fc1\u79fb\u3001\u589e\u6b96\u3001\u5206\u5316\u3001\u6fc0\u6d3b\u7b49\u529f\u80fd\u3002<\/p>\n<p id=\"157O7EET\"><strong>\u2589<\/strong><strong>\u95f4\u63a5\u4f5c\u7528<\/strong><\/p>\n<p id=\"157O7EEU\">\u5e94\u6fc0\u5bf9\u514d\u75ab\u7ec6\u80de\u7684\u95f4\u63a5\u5f71\u54cd\uff0c\u662f\u7531\u7ec4\u6210\u5404\u79cd\u5668\u5b98\u7684\u7ec6\u80de\u4ecb\u5bfc\u7684\u3002<\/p>\n<ul>\n<li id=\"157O7EFP\">\n<p id=\"157O7EEV\">\u5e94\u6fc0\u8c03\u8282\u5185\u76ae\u7ec6\u80de\u4e0a<strong>\u7c98\u9644\u5206\u5b50<\/strong>\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u5f71\u54cd\u514d\u75ab\u7ec6\u80de\u7684\u8fd0\u8f93\u3002<\/p>\n<\/li>\n<li id=\"157O7EFQ\">\n<p id=\"157O7EF0\">\u5e94\u6fc0\u8fd8\u4f1a\u51cf\u5c11\u8840\u6d41\uff0c\u5e76\u901a\u8fc7\u9499\u4fe1\u53f7<strong>\u4e2d\u65ad\u767d\u7ec6\u80de\u8fdb\u5165\u7ec4\u7ec7<\/strong>\u7684\u8fd0\u52a8\u3002<\/p>\n<\/li>\n<li id=\"157O7EFR\">\n<p id=\"157O7EF1\">\u5728\u9020\u8840\u751f\u6001\u4f4d\u4e2d\uff0c\u57fa\u8d28\u7ec6\u80de\u901a\u8fc7\u7279\u5b9a\u914d\u4f53\u7684\u8868\u8fbe\u5f71\u54cd\u514d\u75ab\u7ec6\u80de\u7684\u6210\u719f\u548c\u52a8\u5458\u3002<\/p>\n<\/li>\n<li id=\"157O7EFS\">\n<p id=\"157O7EF2\">\u5f53\u66b4\u9732\u5728\u5e94\u6fc0\u523a\u6fc0\u4e0b\u65f6\uff0c\u8102\u80aa\u7ec6\u80de\u5206\u6cccIL-6\uff0c\u8fd9\u5f71\u54cd\u514d\u75ab\u7ec6\u80de\u7684\u6d3b\u6027\u548c\u62db\u52df\u3002<\/p>\n<\/li>\n<\/ul>\n<p id=\"157O7EF3\"><strong>\u2589<\/strong><strong>\u514d\u75ab\u7ec6\u80de<\/strong><\/p>\n<p id=\"157O7EF4\">\u514d\u75ab\u7ec6\u80de\u8868\u8fbe\u4e59\u9170\u80c6\u78b1\u53d7\u4f53\uff0c\u80be\u4e0a\u817a\u7d20\u548c\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u7684a-\u548c\u03b2-\u80be\u4e0a\u817a\u7d20\u80fd\u53d7\u4f53\uff0c\u4ee5\u53ca\u6fc0\u7d20\u53d7\u4f53\u3002<\/p>\n<p id=\"157O7EF5\">\u795e\u7ecf\u80bd\u7684\u53d7\u4f53\u4e3b\u8981\u5305\u62ecGPCR\uff08\u5982NPY\u3001VIP\uff09\u3002\u5c3d\u7ba1\u4e5f\u5b58\u5728\u4f8b\u5916\uff0c\u5982P\u7269\u8d28\u7684\u53d7\u4f53\u662f\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u5bb6\u65cf\u7684\u6210\u5458\u3002\u8fd9\u4e9b\u53d7\u4f53\u7684\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\u901a\u8fc7\u8f6c\u5f55\u56e0\u5b50\u5982NF-kB\u3001CREB\u3001ERK\u3001STAT\u3001mTOR\u7b49\u8f6c\u5f55\u56e0\u5b50\u8c03\u63a7\u57fa\u56e0\u8868\u8fbe\u3002<\/p>\n<p class=\"f_center\"><img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/hydjzwecgyf2898.jpg\" \/><\/p>\n<p id=\"157O7EF6\"><strong>&#8211;<\/strong><strong>03 &#8211;<\/strong><\/p>\n<p id=\"157O7EF7\"><strong>\u5e94\u6fc0\u5bf9\u80bf\u7624\u7684\u5f71\u54cd<\/strong><\/p>\n<p id=\"157O7EF8\"><strong>\u2589<\/strong><strong>\u4fc3\u8fdb\u80bf\u7624\u8fdb\u5c55<\/strong><\/p>\n<p id=\"157O7EF9\">\u80be\u4e0a\u817a\u7d20\uff08E\uff09\u548c\u53bb\u7532\u80be\u4e0a\u817a\u7d20\uff08N\uff09\u4e0e\u80be\u4e0a\u817a\u7d20\u80fd\u53d7\u4f53\uff08ADR\uff09\u7684\u7ed3\u5408\uff0c\u5bfc\u81f4G\u03b1s\u4ecb\u5bfc\u7684\u817a\u82f7\u9178\u73af\u5316\u9176\u7684\u6fc0\u6d3b\uff0ccAMP\u4ea7\u751f\u589e\u52a0\uff0c\u901a\u8fc7\u4e00\u7cfb\u5217\u4fe1\u53f7\u4f20\u5bfc\uff0c\u6700\u7ec8\u5f15\u8d77IL-6\u3001IL-8\u7b49\u7ec6\u80de\u56e0\u5b50\u5206\u6ccc\u589e\u52a0\u3002IL-8\u5177\u6709\u514d\u75ab\u6291\u5236\uff0c\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80deEMT\uff0c\u589e\u52a0\u80bf\u7624\u8840\u7ba1\u901a\u900f\u6027\u7b49\u4f5c\u7528\uff0c\u4fc3\u8fdb\u80bf\u7624\u8fdb\u5c55\u3002<\/p>\n<p class=\"f_center\"><img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/vyvajo5sbs32899.jpg\" \/><\/p>\n<p id=\"157O7EFA\">\u7b80\u8bc4\uff1a<strong>\u80bf\u7624\u75c5\u4eba\u7684\u5fc3\u7406\u5173\u6000\u548c\u6cbb\u7597\uff0c\u7f13\u89e3\u5e94\u6fc0\uff0c\u53ef\u4ee5\u589e\u5f3a\u6297\u80bf\u7624\u6548\u679c<\/strong>\u3002<\/p>\n<p id=\"157O7EFB\"><strong>\u2589<\/strong><strong>\u4fc3\u8fdb<\/strong><strong>\u708e\u75c7\u6027\u75be\u75c5\u53d1\u5c55<\/strong><\/p>\n<p id=\"157O7EFC\"><strong>\u5e94\u6fc0\u53ef\u4ee5\u5f15\u8d77\u673a\u4f53\u6162\u6027\u708e\u75c7\uff0c\u800c\u6162\u6027\u708e\u75c7\u662f\u5404\u7c7b\u75be\u75c5\u7684\u571f\u58e4<\/strong>\u3002\u4e0b\u56fe\u6765\u81ea\u6d77\u519b\u519b\u533b\u5927\u5b66\u5e94\u6fc0\u533b\u5b66\u7814\u7a76\u6240\u848b\u6625\u96f7\u6559\u6388\u7684\u6587\u7ae0\uff0c\u5f88\u5f62\u8c61\u7684\u89e3\u91ca\u4e86Stress\u7684\u81f4\u75c5\u673a\u5236\u3002<\/p>\n<p class=\"f_center\"><img decoding=\"async\" src=\"http:\/\/demo2.tadke.com\/imgs\/cn2tech\/20220904\/vhkwivwm1ts2900.jpg\" \/><\/p>\n<p id=\"157O7EFD\">\u65e5\u5e38\u5e94\u6fc0\u53cd\u5e94\u662f\u6ecb\u751f\u6162\u6027\u708e\u75c7\u7684\u571f\u58e4<\/p>\n<p id=\"157O7EFE\">Front. Hum. Neurosci. 11:316.<\/p>\n<p id=\"157O7EFF\"><strong>\u5e94\u6fc0\u53ef\u4ee5\u7ed9\u6162\u6027\u708e\u75c7\u521b\u9020\u7684\u571f\u58e4\uff0c\u662f\u708e\u75c7\u6027\u75be\u75c5\u7684\u57fa\u7840\u3002<\/strong><strong>\u5e94\u6fc0\uff0c\u662f\u673a\u4f53\u5bf9\u5916\u754c\u4e8b\u4ef6\u7684\u9002\u5e94\u6027\u53cd\u5e94\uff0c\u5fc5\u4e0d\u53ef\u5c11\u3002\u5f53\u91cd\u8981\u7684\u4e8b\u4ef6\u8fc7\u53bb\u4e86\uff0c\u6211\u4eec\u5e94\u8be5\u53ca\u65f6\u8c03\u6574\u5fc3\u6001\uff0c\u53bb\u9664\u5e94\u6fc0\u7684\u5f71\u54cd\u3002<\/strong><\/p>\n<p id=\"157O7EFG\">[1] A Syndrome produced by Diverse Nocuous Agents.<strong>Nature<\/strong>138, 32\u201334.<\/p>\n<p id=\"157O7EFH\">[2] A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications.<strong>Front. Behav. Neurosci.<\/strong>12, 127<\/p>\n<p id=\"157O7EFI\">[3] Higher Levels of Pro-inflammatory Cytokines Are Associated With Higher Levels of Glutamate in the Anterior Cingulate Cortex in Depressed Adolescents.<strong>Front. Psychiatry<\/strong>12, 642976.<\/p>\n<p id=\"157O7EFJ\">[4]Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress.<strong>Am. J. Physiol. Gastrointest. Liver Physiol<\/strong>. 312, G559\u2013G571.<\/p>\n<p id=\"157O7EFK\">[5] Inflammation: The Common Pathway of Stress-Related Diseases. Front.Hum. Neurosci. 11:316.<\/p>\n<p id=\"157O7EFL\">[6] The neuroimmune response during stress: A physiological perspective\uff0c<strong>Immunity<\/strong>54, September 14, 2021<\/p>\n<p id=\"157O7EFM\"><strong>\u4e58\u5e72\u7ec6\u80de\u4e4b\u4e1c\u98ce\u2014\u2014\u706b\u7206\u201c\u5916\u6ccc\u4f53\u201d\u7684\u5d1b\u8d77<\/strong><\/p>\n<p id=\"157O7EFO\">&#8211; \u79d1\u666e \u60c5\u6000 \u8d23\u4efb &#8211;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u65e5\u5e38\u201c\u5e94\u6fc0\u201d\u6d47\u7684\u6c34\uff0c\u6ecb\u517b\u4e86\u4eba\u4f53\u201c\u6162\u6027\u708e\u75c7\u201d\u7684\u201c\u571f\u58e4\u201d\uff0c\u662f\u4e00\u7cfb\u5217\u75be\u75c5\uff08\u80bf\u7624\u3001\u5fc3\u8840\u7ba1\u3001\u4ee3\u8c22\u75c5\u7b49\uff09\u7684\u57fa\u7840\u3002 1936\u5e74\uff0c\u52a0\u62ff\u5927\u75c5\u7406\u751f\u7406\u5b66\u5bb6Hans Sely\u9996\u5148\u63d0\u51fa\u4e86\u5e94\u6fc0\u7684\u6982\u5ff5[1]\u3002\u5e94\u6fc0\uff08Stress\uff09\uff0c\u4f7f\u673a\u4f53\u80fd\u591f\u5e94\u5bf9\u6311\u6218\u5e76\u6062\u590d\u5185\u7a33\u6001\uff0c\u662f\u673a\u4f53\u4e00\u79cd\u5fc5\u4e0d\u53ef\u5c11\u7684\u9002\u5e94\u6027\u53cd\u5e94\uff0c\u53c8\u79f0\u4e3a\u201c\u5e94\u6fc0\u53cd\u5e94\u201d\u3002\u4e0d\u540c\u7684\u5e94\u6fc0\u6e90\u62e5\u6709\u72ec\u7279\u7684\u7ea0\u6b63\u53cd\u5e94\uff0c\u5176\u4e2d\u514d\u75ab\u7ec6\u80de\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002 &#8211;01 &#8211; \u5e94\u6fc0\u7684\u53d1\u751f \u5e94\u6fc0\uff08Stress\uff09\uff0c\u673a\u4f53\u5bf9\u4e8e\u4efb\u4f55\u9020\u6210\u751f\u7406\u6216\u5fc3\u7406\u6539\u53d8\u7684\u523a\u6fc0\u505a\u51fa\u7684\u4e00\u4e9b\u53cd\u5e94\u3002 \u673a\u4f53\u611f\u53d7\u5230\u751f\u7406\u548c\/\u6216\u5fc3\u7406\u5e94\u6fc0\uff0c\u901a\u8fc7\u4e0b\u4e18\u8111-\u5782\u4f53-\u80be\u4e0a\u817a\uff08HPA\uff09\u8f74\u548c\u4ea4\u611f\u795e\u7ecf-\u80be\u4e0a\u817a-\u9ad3\u8d28\uff08SAM\uff09\u8f74\uff0c\u91ca\u653e\u4ecb\u8d28\uff0c\u4ecb\u8d28\u901a\u8fc7\u7ed3\u5408\u76f8\u5e94\u53d7\u4f53\uff0c\u4f7f\u673a\u4f53\u53d1\u751f\u76f8\u5e94\u6539\u53d8\uff08\u80fd\u529b\u4ee3\u8c22\u52a8\u5458\u3001\u514d\u75ab\u7cfb\u6d3b\u5316\u7b49\uff09\uff0c\u4ee5\u9002\u5e94\u53d1\u751f\u7684\u5e94\u6fc0\u523a\u6fc0\u3002 Front. 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